The Associations of Novel Vitamin D₃ Metabolic Gene CYP27A1 Polymorphism, Adiponectin/Leptin Ratio, and Metabolic Syndrome in Middle-Aged Taiwanese Males

Table 4

Associations between the CYP27A1 rs4674344 SNP and each component of the metabolic syndrome for the adiponectin/leptin ratio.

MetS

WC 90 cm

High BP

Low HDL

High TG

High FBG

No

Yes

No

Yes

No

Yes

No

Yes

No

Yes

No

Yes

401

248

451

198

215

434

487

162

396

253

393

256

A/L ratio

AA genotype

6.80 ± 0.40

1.97 ± 0.16

6.16 ± 0.36

1.70 ± 0.14

6.92 ± 0.60

4.14 ± 0.29

5.83 ± 0.35

2.70 ± 0.36

6.65 ± 0.42

2.42 ± 0.16

6.26 ± 0.42

3.22 ± 0.27

T-carrier

5.28 ± 0.43

1.68 ± 0.17

4.55 ± 0.36

1.45 ± 0.13

4.65 ± 0.60

3.28 ± 0.30

4.26 ± 0.35

2.22 ± 0.37

4.47 ± 0.39

2.69 ± 0.38

4.60 ± 0.41

2.39 ± 0.30

value

0.0287^*

0.3269

0.0451

0.0818

0.2437

0.1344

0.0485

0.1639

0.0106

0.5302

0.0415

0.2517

The model was adjusted for age, BMI, smoking, alcohol drinking, betel nut chewing, CAD, total cholesterol, LDL, CHOL(T)/HDL, and the other 4 components, respectively, for the CYP27A1 rs4674344 SNP. A/L ratio: adiponectin/leptin ratio; MetS: metabolic syndrome; WC: waist circumference; BP: blood pressure; HDL: high density lipoprotein; TG: triglycerides; FBG: fasting blood glucose; BMI: body mass index; CHOL(T): total cholesterol. ^*Significant difference in MetS ( < 0.05); significant difference in 5 MetS components ().