Association of Pre-miR-146a rs2910164 Polymorphism with Papillary Thyroid Cancer

Table 4

The clinical characteristics of the PTC cases by rs2910164 genotypes.

Variables	CC	CG	GG
Gender
Male	99 (25.6)	152 (25.3)	60 (27.1)	0.283	0.868	0.74
Female	287 (74.4)	448 (74.7)	161 (72.9)
Age
<45	268 (70.0)	323 (53.7)	72 (32.6)	79.974	<0.001	<0.001
≥45	115 (30.0)	278 (46.3)	149 (67.4)
History of thyroid disease
Yes	34 (9.0)	61 (10.5)	14 (6.5)	3.109	0.211	0.471
No	345 (91.0)	521 (89.5)	203 (93.5)
Family history
Yes	49 (13.2)	86 (15.2)	23 (10.9)	2.512	0.285	0.634
No	323 (86.8)	481 (84.8)	188 (89.1)
Smoking
Nonsmokers	337 (90.6)	515 (88.3)	189 (87.9)	7.009	0.182	0.1
Smokers	33 (8.9)	62 (10.6)	20 (9.3)
Ex-smokers	2 (0.5)	6 (1.0)	6 (2.8)
Stage
0-I	189 (82.9)	287 (82.7)	107 (78.1)	5.971	0.426	0.521
II	8 (3.5)	17 (4.9)	11 (8.0)
III	14 (6.1)	13 (3.7)	6 (4.4)
IV	17 (7.5)	30 (8.6)	13 (9.5)
Metastasis (pN+)
Yes	145 (39.0)	179 (31.3)	59 (27.7)	9.453	0.009	0.003
No	227 (61.0)	393 (68.7)	154 (72.3)
Location
Unilateral	244 (70.1)	377 (69.8)	149 (74.9)	4.958	0.292	0.217
Bilateral	95 (27.3)	157 (29.1)	47 (23.6)
Isthmus	9 (2.6)	6 (1.1)	3 (1.5)
Diameter
≤1 cm	168 (46.2)	307 (54.1)	113 (52.6)	5.831	0.054	0.07
>1 cm	196 (53.8)	260 (45.9)	102 (47.4)
Benign tumor
Yes	183 (48.3)	309 (52.8)	119 (54.3)	2.673	0.263	0.12
No	196 (51.7)	276 (47.2)	100 (45.7)
PTC/benign
Same side	50 (28.4)	81 (27.3)	36 (31.6)	0.751	0.687	0.632
Opposite sides	126 (71.6)	216 (72.7)	78 (68.4)
Thyroiditis
Yes	30 (7.9)	61 (10.4)	15 (6.8)	3.247	0.197	0.923
No	349 (92.1)	524 (89.6)	204 (93.2)

Fisher’s exact test.
in bold.