Research Article
Association of Pre-miR-146a rs2910164 Polymorphism with Papillary Thyroid Cancer
Table 4
The clinical characteristics of the PTC cases by rs2910164 genotypes.
| Variables | CC | CG | GG | | | |
| Gender | | | | | | | Male | 99 (25.6) | 152 (25.3) | 60 (27.1) | 0.283 | 0.868 | 0.74 | Female | 287 (74.4) | 448 (74.7) | 161 (72.9) | Age | | | | | | | <45 | 268 (70.0) | 323 (53.7) | 72 (32.6) | 79.974 | <0.001 | <0.001 | ≥45 | 115 (30.0) | 278 (46.3) | 149 (67.4) | History of thyroid disease | | | | | | | Yes | 34 (9.0) | 61 (10.5) | 14 (6.5) | 3.109 | 0.211 | 0.471 | No | 345 (91.0) | 521 (89.5) | 203 (93.5) | Family history | | | | | | | Yes | 49 (13.2) | 86 (15.2) | 23 (10.9) | 2.512 | 0.285 | 0.634 | No | 323 (86.8) | 481 (84.8) | 188 (89.1) | Smoking | | | | | | | Nonsmokers | 337 (90.6) | 515 (88.3) | 189 (87.9) | 7.009 | 0.182 | 0.1 | Smokers | 33 (8.9) | 62 (10.6) | 20 (9.3) | Ex-smokers | 2 (0.5) | 6 (1.0) | 6 (2.8) | Stage | | | | | | | 0-I | 189 (82.9) | 287 (82.7) | 107 (78.1) | 5.971 | 0.426 | 0.521 | II | 8 (3.5) | 17 (4.9) | 11 (8.0) | III | 14 (6.1) | 13 (3.7) | 6 (4.4) | IV | 17 (7.5) | 30 (8.6) | 13 (9.5) | Metastasis (pN+) | | | | | | | Yes | 145 (39.0) | 179 (31.3) | 59 (27.7) | 9.453 | 0.009 | 0.003 | No | 227 (61.0) | 393 (68.7) | 154 (72.3) | Location | | | | | | | Unilateral | 244 (70.1) | 377 (69.8) | 149 (74.9) | 4.958 | 0.292 | 0.217 | Bilateral | 95 (27.3) | 157 (29.1) | 47 (23.6) | Isthmus | 9 (2.6) | 6 (1.1) | 3 (1.5) | Diameter | | | | | | | ≤1 cm | 168 (46.2) | 307 (54.1) | 113 (52.6) | 5.831 | 0.054 | 0.07 | >1 cm | 196 (53.8) | 260 (45.9) | 102 (47.4) | Benign tumor | | | | | | | Yes | 183 (48.3) | 309 (52.8) | 119 (54.3) | 2.673 | 0.263 | 0.12 | No | 196 (51.7) | 276 (47.2) | 100 (45.7) | PTC/benign | | | | | | | Same side | 50 (28.4) | 81 (27.3) | 36 (31.6) | 0.751 | 0.687 | 0.632 | Opposite sides | 126 (71.6) | 216 (72.7) | 78 (68.4) | Thyroiditis | | | | | | | Yes | 30 (7.9) | 61 (10.4) | 15 (6.8) | 3.247 | 0.197 | 0.923 | No | 349 (92.1) | 524 (89.6) | 204 (93.2) |
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Fisher’s exact test. in bold.
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