Association of Pre-miR-146a rs2910164 Polymorphism with Papillary Thyroid Cancer
Table 5
Association of rs2910164 and clinical characteristics under different models of inheritance with OR (95% CI) (adjusted by age and gender).
Characteristics
Codominant 1
Codominant 2
Dominant
Recessive
Overdominant
Log-additive
Stage (III-IV versus 0–II)
0.65 (0.39–1.09)
0.75 (0.37–1.55)
0.67 (0.41–1.10)
1.02 (0.55–1.91)
0.73 (0.46–1.13)
0.82 (0.57–1.18)
Metastasis (yes versus no)
0.84 (0.63–1.12)
0.86 (0.58–1.28)
0.85 (0.64–1.11)
0.97 (0.68–1.37)
0.88 (0.69–1.14)
0.91 (0.75–1.11)
Location (bilateral versus unilateral)
1.20 (0.88–1.63)
0.99 (0.64–1.51)
1.15 (0.85–1.55)
0.87 (0.60–1.26)
1.20 (0.92–1.57)
1.02 (0.83–1.26)
Diameter (>1 cm versus ≤1 cm)
0.73 (0.56–0.96)
0.79 (0.55–1.13)
0.74 (0.57–0.96)
0.97 (0.71–1.32)
0.80 (0.63–1.01)
0.86 (0.72–1.03)
Benign tumor (yes versus no)
1.12 (0.86–1.46)
1.10 (0.77–1.56)
1.12 (0.87–1.44)
1.02 (0.75–1.38)
1.08 (0.86–1.36)
1.06 (0.89–1.26)
Thyroiditis (yes versus no)
1.47 (0.92–2.36)
1.04 (0.53–2.03)
1.37 (0.87–2.18)
0.80 (0.44–1.43)
1.45 (0.97–2.19)
1.08 (0.80–1.47)
Codominant 1: CG versus CC; codominant 2: GG versus CC; dominant: CG/GG versus CC; recessive: GG versus CC/CG; overdominant: CG versus CC/GG. Significant OR (95% CI) in bold.
