Methylation of the Corticotropin Releasing Hormone Gene Promoter in BeWo Cells: Relationship to Gene Activity

Figure 3

DNA sequence of the CRH proximal promoter. The methylatable CpG dinucleotides are in boldface and are numbered 1 to 9. The canonical CRE, which contains CpG2, and the noncanonical cAMP-response regions are underlined. The two major transcription initiation sites are flagged by the arrows.