|
| Study | Year | Study type | Patient number | Steroids | Bisphosphonate | Mean Age at Bisphosphonate Initiation | Results | Comments |
|
|
Houston et al. [52] | 2014 | Retrospective cohort | 39 | 29 were on prednisone or deflazacort | Alendronate PO | 12 years old
(no range given) | -score trended up at the hip with alendronate, but it is not statistically significant | 10 did not receive alendronate, varying dosages of alendronate used |
|
| Sbrocchi et al. [53] | 2012 | Retrospective observational | 7 | All but 1 were reported as prednisone equivalents | Pamidronate IV 9 mg/kg/year or zoledronic acid IV 0.1 mg/kg/year | 11.6 years old (range: 8.5–14.3 years old) | Improved back pain and stabilization to improvement in vertebral height ratios for the previously fractured vertebrae | Only patients with vertebral fractures were included in the study |
|
| Gordon et al. [54] | 2011 | Retrospective observational | 44 | 5 prednisone only; 13 changed from prednisone to deflazacort; 26 deflazacort only | 11 used pamidronate only; 1 changed from pamidronate to alendronate; 3 alendronate only; 1 clodronate only | 12.5 years old (range: 7–23 years old) | Survival curve showed improvement in survival rate (, log-rank test); also, possible therapy duration effect could be present , log-rank test) | Pamidronate was IV; alendronate was PO; clodronate was PO |
|
| Atance et al. [55] |
2011 | Case reports | 3 | 2 on deflazacort | Alendronate 10 mg daily PO | 11.4 years old (range: 8.1–15.8 years old) | Reduced back pain and improved BMD | Only 3 patients were reported |
|
| Hawker et al. [56] | 2005 | Before-after trial | 23 | All on deflazacort | Alendronate 0.08 mg/kg/day PO | 10.8 years old (range: 6.9–15.6 years old) | Positive effect on BMD and -scores, better BMD outcome when given early in the course of disease | Also received 750 mg daily calcium and 1000 IU vitamin D |
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