Sexual Dimorphisms of Adrenal Steroids, Sex Hormones, and Immunological Biomarkers and Possible Risk Factors for Developing Rheumatoid Arthritis

Table 6

Multiple regression model of serum inflammatory biomarker outcomes including variables that predicted sex plus E2/T ratio and actual sex status.

Independent variables in total subjects	ASAA outcome		sIL-2Rα outcome		sTNF-R1 outcome
	()		()		()
	Beta	values	Beta	values	Beta	values
17-OH P5	−0.039	0.725	0.021	0.863	0.088	0.327
DHEA	−0.113	0.519	0.093	0.463	0.228	0.015
Adione	0.080	0.490	−0.091	0.385	−0.241	0.002
DHEAS	0.141	0.323	0.012	0.928	−0.166	0.084
LH	0.092	0.312	0.016	0.887	0.052	0.528
E2/T ratio	0.270	<0.001	−0.040	0.694	−0.029	0.696
Sex (F = 0, M = 1)	−0.434	0.044	−0.333	0.075	0.682	<0.001
Entry age	0.194	0.032	−0.043	0.672	−0.066	0.371
Independent variables in control subjects	ASAA outcome		sIL-2Rα outcome		sTNF-R1 outcome
	()		()		()
	Beta	values	Beta	values	Beta	values
17-OH P5	−0.113	0.377	0.101	0.456	0.085	0.380
DHEA	−0.094	0.631	0.143	0.296	0.230	0.024
Adione	0.173	0.174	−0.110	0.356	−0.257	0.004
DHEAS	0.089	0.622	−0.102	0.519	−0.110	0.341
LH	0.099	0.339	0.063	0.622	0.085	0.361
E2/T ratio	0.296	0.002	−0.074	0.515	0.006	0.942
Sex (F = 0, M = 1)	−0.321	0.215	−0.229	0.278	0.692	<0.001
Entry age	0.164	0.100	0.004	0.970	−0.053	0.537
Independent variables in pre-RA subjects	ASAA outcome		sIL-2Rα outcome		sTNF-R1 outcome
	()		()		()
	Beta	values	Beta	values	Beta	values
17-OH P5	0.296	0.269	−0.105	0.762	−0.078	0.786
DHEA	0.071	0.892	0.053	0.893	0.136	0.671
Adione	−0.589	0.115	−0.096	0.729	−0.131	0.545
DHEAS	0.015	0.962	0.306	0.241	−0.283	0.193
LH	0.049	0.835	−0.295	0.240	−0.111	0.584
E2/T ratio	0.018	0.940	0.316	0.326	−0.476	0.073
Sex (F = 0, M = 1)	−0.734	0.215	−0.584	0.224	0.399	0.295
Entry age	0.198	0.432	−0.145	0.519	−0.118	0.506

Standardized beta coefficients from linear regression of log-transformed, reported NEI biomarkers.