Research Article
Sexual Dimorphisms of Adrenal Steroids, Sex Hormones, and Immunological Biomarkers and Possible Risk Factors for Developing Rheumatoid Arthritis
Table 6
Multiple regression model of serum inflammatory biomarker outcomes including variables that predicted sex plus E2/T ratio and actual sex status.
| Independent variables in total subjects | ASAA outcome | sIL-2Rα outcome | sTNF-R1 outcome | () | () | () | Beta | values | Beta | values | Beta | values |
| 17-OH P5 | −0.039 | 0.725 | 0.021 | 0.863 | 0.088 | 0.327 | DHEA | −0.113 | 0.519 | 0.093 | 0.463 | 0.228 | 0.015 | Adione | 0.080 | 0.490 | −0.091 | 0.385 | −0.241 | 0.002 | DHEAS | 0.141 | 0.323 | 0.012 | 0.928 | −0.166 | 0.084 | LH | 0.092 | 0.312 | 0.016 | 0.887 | 0.052 | 0.528 | E2/T ratio | 0.270 | <0.001 | −0.040 | 0.694 | −0.029 | 0.696 | Sex (F = 0, M = 1) | −0.434 | 0.044 | −0.333 | 0.075 | 0.682 | <0.001 | Entry age | 0.194 | 0.032 | −0.043 | 0.672 | −0.066 | 0.371 |
| Independent variables in control subjects | ASAA outcome | sIL-2Rα outcome | sTNF-R1 outcome | () | () | () | Beta | values | Beta | values | Beta | values |
| 17-OH P5 | −0.113 | 0.377 | 0.101 | 0.456 | 0.085 | 0.380 | DHEA | −0.094 | 0.631 | 0.143 | 0.296 | 0.230 | 0.024 | Adione | 0.173 | 0.174 | −0.110 | 0.356 | −0.257 | 0.004 | DHEAS | 0.089 | 0.622 | −0.102 | 0.519 | −0.110 | 0.341 | LH | 0.099 | 0.339 | 0.063 | 0.622 | 0.085 | 0.361 | E2/T ratio | 0.296 | 0.002 | −0.074 | 0.515 | 0.006 | 0.942 | Sex (F = 0, M = 1) | −0.321 | 0.215 | −0.229 | 0.278 | 0.692 | <0.001 | Entry age | 0.164 | 0.100 | 0.004 | 0.970 | −0.053 | 0.537 |
| Independent variables in pre-RA subjects | ASAA outcome | sIL-2Rα outcome | sTNF-R1 outcome | () | () | () | Beta | values | Beta | values | Beta | values |
| 17-OH P5 | 0.296 | 0.269 | −0.105 | 0.762 | −0.078 | 0.786 | DHEA | 0.071 | 0.892 | 0.053 | 0.893 | 0.136 | 0.671 | Adione | −0.589 | 0.115 | −0.096 | 0.729 | −0.131 | 0.545 | DHEAS | 0.015 | 0.962 | 0.306 | 0.241 | −0.283 | 0.193 | LH | 0.049 | 0.835 | −0.295 | 0.240 | −0.111 | 0.584 | E2/T ratio | 0.018 | 0.940 | 0.316 | 0.326 | −0.476 | 0.073 | Sex (F = 0, M = 1) | −0.734 | 0.215 | −0.584 | 0.224 | 0.399 | 0.295 | Entry age | 0.198 | 0.432 | −0.145 | 0.519 | −0.118 | 0.506 |
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Standardized beta coefficients from linear regression of log-transformed, reported NEI biomarkers.
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