The Protective Effect of Beraprost Sodium on Diabetic Nephropathy by Inhibiting Inflammation and p38 MAPK Signaling Pathway in High-Fat Diet/Streptozotocin-Induced Diabetic Rats
Table 5
HFD/STZ-induced inflammation-related parameters of rats in experiment (, ).
CN group
T2DM group
BPS group
IL-6 (ng/L)
27.39 ± 1.12
51.80 ± 4.23
46.43 ± 5.11
hs-CRP (g/L)
1.78 ± 0.28
2.44 ± 0.09
2.05 ± 0.14
TNF- (ng/L)
44.42 ± 3.17
87.65 ± 6.85
68.59 ± 4.90
ET-1 (ng/L)
22.05 ± 2.98
49.72 ± 6.20
32.21 ± 3.15
SOD (/ml)
42.85 ± 2.57
8.24 ± 2.16
12.11 ± 2.03
MDA (nmol/L)
1.40 ± 0.29
6.20 ± 0.73
1.75 ± 0.40
GSH (mgGSH/L)
21.01 ± 2.93
6.90 ± 1.16
10.31 ± 1.80
MPO (/L)
25.07 ± 12.64
163.35 ± 22.62
118.73 ± 27.55
NO (mol/L)
60.81 ± 6.88
42.00 ± 7.03
55.82 ± 7.89
and T2DM group and BPS group compared with CN group rats and and BPS group compared with the T2DM group.
