The Protective Effect of Beraprost Sodium on Diabetic Nephropathy by Inhibiting Inflammation and p38 MAPK Signaling Pathway in High-Fat Diet/Streptozotocin-Induced Diabetic Rats
Table 8
Western blot results of p-p38, t-p38, TNF-α, TGF-β1, MMP-9, COX-2, CREB, and FN in kidney tissues of rats in experiment (, ).
Optical density ratios
CN group
T2DM group
BPS group
p-p38 MAPK/-actin
0.8683 ± 0.0388
1.3051 ± 0.2737
1.1326 ± 0.0663
t-p38 MAPK/-actin
1.1202 ± 0.0263
1.1196 ± 0.0228
1.1029 ± 0.0184
TNF-/-actin
1.010 ± 0.0458
1.2913 ± 0.0219
1.1060 ± 0.0220
TGF-1/-actin
1.1074 ± 0.0225
1.1215 ± 0.2794
1.0832 ± 0.2881
MMP-9/-actin
0.4862 ± 0.0121
0.9954 ± 0.0258
0.8375 ± 0.0796
COX-2/-actin
0.7056 ± 0.0373
1.087 ± 0.0105
0.9017 ± 0.03756
CREB/-actin
0.7996 ± 0.0258
1.199 ± 0.0238
0.9986 ± 0.0163
FN/-actin
1.1235 ± 0.0339
1.2778 ± 0.0226
1.2017 ± 0.0224
and T2DM group and BPS group compared with CN group rats and and BPS group compared with the T2DM group.
