Research Article

Extending the Impact of RAC1b Overexpression to Follicular Thyroid Carcinomas

Table 1

Clinical data: ID, patient identification; M, male; F, female; HCC, Hürthle cells carcinoma; FTC, follicular thyroid carcinoma; TNM, tumor, node, and metastases staging; WI, widely invasive; EI, extrathyroidal invasion; M, multifocal; A, angioinvasion; PD, poorly differentiated areas; 131I, number of 131I treatments; TT, total thyroidectomy; HT, hemithyroidectomy; TTC, total thyroidectomy with cervical dissection; TG, thyroglobulin; M1, distant metastases; n.t., not tested; NED, no evidence of disease; BED, biochemical evidence of disease; SED, structural evidence of disease; D; death due to disease; I, remission or biochemical disease; II, structural disease or death due to disease.

PatientHistopathologyTreatmentFollow-upClinical outcomeMolecular analysis
IDGenderAge at diagnosis (years)TNMPatternWI/EI/M/A/PDSurgery/131IYearsLast TG (ng/mL)Anti-TGM1NEDBEDSEDDGroupRAS
(K/N/H)
RAC1b overexpression

1F68T2NxMxHCC(−/−/−/+/−)TT/15<0.20I(—/—/—)
2F45T3NxMxHCC(−/−/−/+/−)HT/081.7n.t.I(—/—/—)
3F40T3NxMxFTC(−/−/−/+/−)HT/071.9n.t.I(—/Q61R/—)
4M38T3NxMxFTC(−/−/−/−/−)TT/113<0.20I(—/—/—)
5F70T3NxMxFTC(−/−/−/+/−)TT/212<0.20I(—/—/—)
6F63T3NxMxFTC(−/−/−/+/−)TT/17<0.20I(—/—/—)
7F57T2NxMxHCC(−/−/−/−/−)HT/0168.7n.t.I(—/—/—)+
8F59T2NxMxFTC (−/−/−/−/−)TT/115<0.20I(—/—/—)+
9M38T2NxMxFTC (−/−/−/−/−)TT/111<0.20I(—/—/—)
10F39T3NxMxFTC (+/−/−/+/+)TT/29<0.20I(—/—/—)
11F34T2NxMxHCC(−/−/−/−/−) HT/0711.1n.t.I(—/—/—)
12F39T2NxMxFTC(−/−/−/−/−) TT/272.7n.t.I(—/—/—)
13F81T3NxMxHCC(−/+/−/−/−)TT/14<0.20I(—/—/n.t.)
14M39T3NxMxFTC (−/−/−/−/−)TT/17<0.20I(—/—/—)
15F49TxNxMxFTC (−/−/−/+/−)HT/023<0.20In.t.
16F65T2NxMxFTC (−/−/−/+/−)HT/06<0.20I(—/—/—)
17F71T1NxM1HCC(+/+/+/+/−)TT/243000000Lung adrenal glandIIn.t.
18F42T3NxMxHCC(−/−/−/+/+)TT/61021080LungII(—/—/—)+
19M 58T3NxM1FTC(−/−/−/+/−)TT/403760BoneII(—/Q61R/—)+
20M 53T2NxMxHCC(+/−/+/+/−)TT/476320LungII(—/—/—)+
21M 69T2NxM1FTC (−/−/−/+/−)TT/5246680Bone, inguinal nodeII(—/—/—)+
22M 64T4aN1bMxFTC (+/+/−/+/+)TTC/3228.60LungII(—/—/—)+
23F87T3NxMxFTC (+/+/−/+/−)TT/51043500n.t.Soft tissuesII(—/Q61L/—)