Role of Nox2 and p22phox in Persistent Postoperative Hypertension in Aldosterone-Producing Adenoma Patients after Adrenalectomy
Table 1
Clinical and endocrinologic features of patients with APA and NFA in this study.
Variable
APA ()
NFA ()
value
Age (y)
44 ± 10
53 ± 14
<0.05
Sex (male/female)
9/20
6/8
NS
BMI (kg/m2)
22.0 ± 2.5
23.6 ± 3.6
NS
SBP (mmHg)
165 ± 14.1
136 ± 15.2
<0.01
DBP (mmHg)
100 ± 8.4
82 ± 9.7
<0.01
Duration of hypertension (y)
4.0 (0.5–7.0)
1.3 (0–10.0)
NS
Antihypertensive medication (grade)
2.0 (1.0–3.0)
1.0 (0–1.0)
<0.05
Diameter (cm)
1.6 (1.2–2.35)
2.9 (1.8–3)
<0.05
Volume (cm3)
2.6 (1.5–5.3)
8.1 (4.1–13.2)
<0.05
Baseline PRA (ng/mL⋅h−1)
0.1 (0.1–0.2)
2.3 (1.3–2.5)
<0.01
Baseline PAC (pg/mL)
609 (410–993)
113 (92.1–141.3)
<0.01
Baseline ARR (pg/mL per ng/mL⋅h−1)
6130 (2275–11600)
52 (40.6–81.2)
<0.01
Supine PRA (ng/mL⋅h−1)
0.11 (0.1–0.2)
0.1 (0.03–0.41)
NS
Supine PAC (pg/mL)
537 (387–739)
1185.5 (721–1436)
<0.05
Supine ARR (pg/mL per ng/mL⋅h−1)
488.2 (194.4–785.3)
768.6 (235–5452)
NS
Orthostatic PRA (ng/mL⋅h−1)
0.25 (0.065–0.37)
0.27 (0.14–0.41)
NS
Orthostatic PAC (pg/mL)
442 (327–655.2)
851.5 (549.8–1243.8)
<0.05
Orthostatic ARR (pg/mL per ng/mL⋅h−1)
295 (116.5–982.7)
260 (179.4–456.1)
NS
Serum K+ (mmol/L)
3.0 (2.8–3.4)
3.9 (3.6–4.2)
<0.01
Serum Na+ (mmol/L)
142.4 (140.5–144.8)
141.6 (140.5–143.6)
NS
Urinary K+ (mmol/24 h)
71.4 (55.4–97.2)
33.9 (25.4–41.1)
<0.01
Urinary Na+ (mmol/24 h)
151.7 (115.8–181)
92.0 (59.5–167.5)
<0.05
Urinary aldosterone (ug/24 h)
28.6 (20.4–51.2)
6.0 (4.8–8.8)
<0.01
BMI, body mass index; SBP, systolic blood pressure; DBP, diastolic blood pressure; PAC, plasma aldosterone concentration; PRA, plasma renin activity; ARR, aldosterone-to-renin ratio. Data are given as mean ± SD or median (interquartile range) as appropriate.
