Role of Nox2 and p22phox in Persistent Postoperative Hypertension in Aldosterone-Producing Adenoma Patients after Adrenalectomy
Table 2
Clinical and biological data of patients with or without ZG hyperplasia.
Variable
Patients with ZG hyperplasia ()
Patients without ZG hyperplasia ()
value
Preoperative baseline, PAC, pg/mL
658 (421–1236)#
537 (387–879)#
NS
Postoperative baseline, PAC, pg/mL
329 (153–567)
27 (12–57)
<0.01
Preoperative baseline, PRA, ng/mL⋅h−1
0.1 (0.1–0.2)#
0.1 (0.0–0.4)#
NS
Postoperative baseline, PRA, ng/mL⋅h−1
1.2 (1.0–2.4)
2.7 (0.7–5.2)
<0.01
Preoperative baseline, ARR, pg/mL per ng/mL⋅h−1
488.2 (194.4–785.3)#
768.6 (235.1–5452)#
NS
Postoperative baseline, RR, pg/mL per ng/mL⋅h−1
126.5 (78.5–359.7)
4.5 (1.2–21.2)
<0.01
Preoperative-urinary, aldosterone, µg/24 h
24.0 (19.3–40.2)
40.6 (26.9–54.4)#
NS
Postoperative-urinary, aldosterone, µg/24 h
16.8 (8.5–28.1)
6.38 (1.0–14.6)
<0.05
Diameter, cm
1.6 (1.2–2.4)
1.8 (1.3–2.4)
NS
Preoperative SBP, mmHg
167.6 ± 13.7#
167.9 ± 21.2
NS
Postoperative SBP, mmHg
145.2 ± 7.5
123.6 ± 13.1
<0.01
Preoperative DBP, mmHg
101.6 ± 8.6#
95.9 ± 7.7
NS
Postoperative DBP, mmHg
94.7 ± 7.1
82.9 ± 5.5
<0.01
Preoperative serum K+, mmol/L
3.0 ± 0.5#
2.8 ± 0.3
<0.05
Postoperative serum K+, mmol/L
3.8 ± 0.3
3.87 ± 0.24
NS
SBP decline, mmHg
22.4 ± 13.1
44.25 ± 16.4
<0.01
DBP decline, mmHg
7.0 ± 11.8
13.0 ± 8.8
NS
Serum K+ rise, mmol/L
0.7 ± 0.5
1.1 ± 0.3
<0.05
PAC, plasma aldosterone concentration; PRA, plasma renin activity; ARR, aldosterone-to-renin ratio; SBP, systolic blood pressure; DBP, diastolic blood pressure. Data are given as mean ± SD or median (interquartile range), as appropriate. # preoperatively versus postoperatively in patients with ZG hyperplasia; preoperatively versus postoperatively in patients without ZG hyperplasia.
