No significant differences were observed between groups in percentile changes in blood pressure or the levels of lipids, inflammatory markers, C-reactive protein, or C peptide.
There were no significant differences between the groups in changes in blood pressure, the level of insulin sensitivity factor (ISF), ideal blood glucose (IBG), or insulin-to-carbohydrate ratio (ICR).
Peripheral insulin sensitivity was increased in the group that received metformin. No differences were observed in the levels of blood lipids, insulin-like growth factor I (IGF-I), or IGF-binding protein-1 (IGFBP-1) between the two groups.
No changes in insulin sensitivity were observed according to the frequently sampled intravenous glucose tolerance test (FSIGT). Cholesterol and triglyceride levels did not change during the study period.