Maternal High-Fat Diet during Pregnancy and Lactation Influences Obestatin and Ghrelin Concentrations in Milk and Plasma of Wistar Rat Dams and Their Offspring
Table 2
Body weight, blood glucose, and plasma triglycerides in rat dams (a) and neonates (b).
(a)
Mating
Pregnancy
Lactation
First d
14th d
14th d
21st d
BD
HF
BD
HF
BD
HF
BD
HF
Body weight (g)
246 ± 12
224 ± 6
280 ± 14
259 ± 8
285 ± 17
253 ± 6
283 ± 19
253 ± 6
Blood glucose (mmol/L)
7.38 ± 0.1
8.27 ± 0.12
6.88 ± 0.38
7.16 ± 0.11
11.44 ± 0.61
8.61 ± 0.61
11.33 ± 1.33
9.88 ± 0.72
Plasma triglycerides (mmol/L)
1.1 ± 0.1
0.8 ± 0.1
2.7 ± 0.3
3.2 ± 0.8
1.0 ± 0.1
2.9 ± 0.5
1.3 ± 0.1
2.8 ± 0.5
BD: females fed with standard breeding diet during pregnancy and lactation; HF: females fed with high-fat diet during pregnancy and lactation. Data are expressed as means ± SEM. Statistical differences between days within BD treatment. Statistical differences between days within HF treatment. Statistical differences between BD and HF group (, , ).
(b)
First d
14th d
21st d
BDO
HFO
BDO
HFO
BDO
HFO
Body weight (g)
6.2 ± 0.2
5.9 ± 0.25
22 ± 0.3
27 ± 0.3
37 ± 1.3
45 ± 1.1
Blood glucose (mmol/L)
4.3 ± 0.6
4.1 ± 0.4
7.8 ± 0.4
7.4 ± 0.6
9.4 ± 1.2
9.9 ± 2.0
Plasma triglycerides (mmol/L)
1.7 ± 0.2
1.0 ± 0.3
0.6 ± 0.1
2.1 ± 0.2
2.3 ± 0.4
4.8 ± 0.8
BDO: rat neonates from females fed with standard breeding diet during pregnancy and lactation; HFO: rat neonates from females fed with high-fat diet during pregnancy and lactation. Data are expressed as means ± SEM. Statistical differences between days within BDO treatment. Statistical differences between days within HFO treatment. Statistical differences between BDO and HFO group (, , ).
