Tetrahydro-iso-alpha Acids Antagonize Estrogen Receptor Alpha Activity in MCF-7 Breast Cancer Cells

Figure 2

Effect of commercial hop extracts on proliferation (a) and metabolic activity (b) of MCF-7 and MDA-MB-231 cells in serum-complete condition. Cells were grown during 72 h in the absence (control) or presence of indicated hop extracts at 0.001 and 0.01%. Cell proliferation was measured by crystal violet staining and metabolic activity by the MTT method. Measurements were performed in sixplicate. Data refer to the mean value ± SD of a representative experiment performed independently three times.

(a)

(b)