Efficacy of Once Daily versus Divided Daily Administration of Low Daily Dosage (15 mg/Day) of Methimazole in the Induction of Euthyroidism in Graves’ Hyperthyroidism: A Randomized Controlled Study

Table 2

Changes in serum FT₃ and FT₄ levels during treatment with 15 mg/day OD-MMI and 15 mg/day DD-MMI.

	Week 0	Week 2	Week 4	Week 8	Week 12
Serum FT3 (pmol/L)
OD-MMI (21 cases)	29.24 ± 14.12	11.07 ± 3.30	8.61 ± 3.14	5.71 ± 2.08	5.53 ± 2.11
DD-MMI (23 cases)	23.96 ± 13.74	11.60 ± 4.73	8.24 ± 3.43	6.16 ± 4.11	6.59 ± 5.21
Serum FT4 (pmol/L)
OD-MMI (21 cases)	68.47 ± 27.80	34.62 ± 10.68	26.64 ± 10.17	17.50 ± 6.69	16.35 ± 5.92
DD-MMI (23 cases)	56.76 ± 23.94	35.14 ± 11.07	26.39 ± 10.55	17.89 ± 10.17	18.66 ± 11.46

Data are demonstrated as mean ± standard deviation. 15 mg/day OD-MMI, 15 mg/day of methimazole administered once daily; 15 mg/day DD-MMI, 15 mg/day of methimazole administered dividedly in 5 mg three times a day. No significant difference in all parameters between the two groups.