Increased Chromosomal and Oxidative DNA Damage in Patients with Multinodular Goiter and Their Association with Cancer

Table 3

Spearman’s rho correlation coefficient and significance values for age, TSH, fT4, and thyroid nodule size with CBMN-cyt assay parameters and plasma 8-OHdG levels in patients with multinodular goiter and control subjects.

	MN; frequency (%)	NPB; frequency (%)	NBUD; frequency (%)	Frequency; of apoptotic; cells (%)	Frequency; of necrotic; cells (%)	NDI	Plasma; 8-OHdG; levels
Patients with; multinodular goiter
Age (years)
	−0.017	−0.133	0.065	0.205	0.214	−0.411	0.240
	0.929	0.475	0.730	0.269	0.247	0.022	0.194
TSH (mIU/L)
	−0.089	0.029	−0.248	0.381	0.194	−0.049	0.318
	0.646	0.880	0.195	0.042	0.312	0.802	0.093
fT4 (ng/dL)
	0.166	0.005	0.061	−0.197	−0.099	0.362	−0.512
	0.388	0.980	0.755	0.306	0.611	0.053	0.005
Thyroid nodule size (mm)
	−0.243	0.105	0.110	−0.178	−0.114	−0.114	−0.279
	0.276	0.642	0.628	0.428	0.615	0.615	0.209
Control subjects
Age (years)
	0.176	0.640	0.578	0.053	−0.190	−0.339	0.319
	0.485	0.004	0.012	0.833	0.449	0.169	0.197
TSH (mIU/L)
	0.142	−0.150	−0.354	0.075	0.424	−0.039	0.317
	0.574	0.552	0.149	0.769	0.080	0.877	0.200
fT4 (ng/dL)
	0.342	−0.282	−0.322	−0.016	0.247	−0.153	−0.473
	0.165	0.257	0.193	0.950	0.322	0.545	0.047

Correlation is significant at the 0.05 level, and correlation is significant at the 0.01 level.
BN cells, binucleated cells; MN, micronucleus; NBUDs, nuclear buds; NPBs, nucleoplasmic bridges; NDI, nuclear division index; and 8-OHdG, 8-hydroxy-2′-deoxyguanosine.