Research Article
Therapeutic Outcomes of Patients with Multifocal Papillary Thyroid Microcarcinomas and Larger Tumors
Table 4
Clinical features of multifocal papillary thyroid cancer in cancer mortality.
| | Clinical characteristics | All patients | Cancer mortality | Survival | value |
| | Patient number | 626 (100.0) | 25 (4.0) | 601 (96.0) | | | Gender, female | 499 (79.7) | 9 (36.0) | 490 (81.5) | <0.001 | | Age at diagnosis (year) | 46.5 ± 13.5 | 61.0 ± 13.8 | 45.9 ± 13.2 | <0.001 | | Mean tumor size (cm) | 2.1 ± 1.4 | 3.2 ± 2.3 | 2.0 ± 1.3 | <0.001 | | 1-month postoperative serum Tg level (ng/mL) | 184.2 ± 1551.1 | 2060.6 ± 6608.4 | 112.8 ± 834.4 | <0.001 | | Operative method | | Total thyroidectomy | 595 (95.0) | 25 (100.0) | 570 (94.8) | 0.244 | | Less than total thyroidectomy | 31 (5.0) | — | 31 (5.2) | | | TNM stage | | Stage I | 390 (62.3) | 2 (8.0) | 388 (64.6) | <0.001 | | Stages II–IV | 236 (37.7) | 23 (92.0) | 213 (35.4) | | | Nonremission | 131 (20.9) | 24 (96.0) | 107 (17.8) | <0.001 | | Follow-up period (year) | 7.1 ± 5.3 | 4.9 ± 3.9 | 7.2 ± 5.4 | 0.032 | | Postoperative 131I accumulative dose (mCi) | 153.7 ± 222.2 | 341.1 ± 317.4 | 146.0 ± 213.8 | <0.001 | | Radiation therapy | 28 (4.5) | 14 (56.0) | 14 (2.3) | <0.001 | | 2nd primary cancer | 49 (7.8) | 2 (8.0) | 47 (7.8) | 0.974 | | Diabetes mellitus | 61 (9.7) | — | 61 (10.1) | 0.094 | | Lymph node metastasis | 197 (31.5) | 14 (56.0) | 183 (30.4) | 0.007 | | Soft tissue invasion | 153 (24.4) | 18 (72.0) | 135 (22.5) | <0.001 | | Distant metastasis | 39 (6.2) | 14 (56.0) | 25 (4.2) | <0.001 |
|
|
Number (%); mean ± SD.
|
