Chronic Hyperglycemia Modulates Rat Osteoporotic Cortical Bone Microarchitecture into Less Fragile Structures

Table 1

Physiological and biochemical markers of the studied animal groups: healthy control (sham), ovariectomized (OVX), hyperglycemic (STZ), and hyperglycemic-ovariectomized (STZ + OVX).

	Sham	OVX	STZ	STZ + OVX
Body weight (g) at D 0	200.31 ± 5.92	206.57 ± 6.53	239.55 ± 4.42^a	249.16 ± 10.41^a,b
Body weight (g) at D 60	218.49 ± 4.97	274.74 ± 9.98^aa	270.40 ± 10.37^a	300.49 ± 10.41^aaa
E2 (pg/ml)	16.50 ± 2.63	<DL	31.89 ± 7.71	<DL
Glycemia (mg/dl)	66.00 ± 15.20	87.33 ± 10.45	167.33 ± 7.54^aa,b	198.00 ± 21.65^aaa,bb
Triglycerides (mg/dl)	31.29 ± 2.29	34.29 ± 3.69	53.75 ± 5.90^a	57.71 ± 6.07^a
Cholesterol (mg/dl)	84.57 ± 3.77	97.00 ± 4.84	90.63 ± 4.77	98.67 ± 4.33
HDL (mg/dl)	39.33 ± 2.46	45.33 ± 2.91	38.2 ± 3.0	37.50 ± 5.86
LDL (mg/dl)	38.17 ± 3.23	49.14 ± 5.57	39.25 ± 4.30	43.71 ± 3.26
Calcemia (mg/dl)	10.47 ± 0.19	9.76 ± 0.15^a	10.26 ± 0.23	9.94 ± 0.29
Urine 12 h (ml)	3.9 ± 0.69	4.3 ± 0.72	7.2 ± 0.66^aa,b	7.6 ± 0.75^aa,b
Calciuria (mg/dl)	31.48 ± 4.47	65.14 ± 3.29^a,c,d	34.68 ± 4.77	37.59 ± 6.13
Ca^2+ clearance (ml/min)	0.016 ± 0.002	0.040 ± 0.002^a	0.034 ± 0.005	0.040 ± 0.007^a
CTX (ng/ml)	9.38 ± 0.64	15.45 ± 1.86^a,c	9.43 ± 0.91	15.88 ± 1.43^a,c
PINP (ng/ml)	14.66 ± 1.26	21.33 ± 0.61^a	18.58 ± 1.58	25.01 ± 2.15^aa
PINP/CTX	1.57 ± 0.06	1.39 ± 0.11	1.97 ± 0.0.09^bb	1.66 ± 0.13

Average results ± standard error; per group; ^a, ^aa, ^aaa compared to sham; ^b, ^bb compared to OVX; ^c, ^d compared to STZ + OVX; DL: detection limit = 11.8 pg/ml.