Chronic Hyperglycemia Modulates Rat Osteoporotic Cortical Bone Microarchitecture into Less Fragile Structures

Table 2

Bone parameters (femur and tibia) of the studied animal groups: healthy control (sham), ovariectomized (OVX), hyperglycemic (STZ), and hyperglycemic-ovariectomized (STZ + OVX).

	Sham	OVX	STZ	STZ + OVX
Femur bone calcium (%)	14.17 ± 1.05	11. 07 ± 0.35^a	11.96 ± 0.46	10.31 ± 0.41^aa
Femur diameter/BW (μ/g)	12.60 ± 0.45	9.28 ± 0.43^aaa	11.03 ± 0.45	10.92 ± 0.51
Femur mass/BW (μg/g)	2.68 ± 0.07	2.58 ± 0.05	2.74 ± 0.06	2.64 ± 0.02
Tibia medullary canal perimeter (mm)	4.63 ± 0.09	6.31 ± 0.25^a	6.42 ± 0.26^aa	6.27 ± 0.32^a
Tibia cortical thickness (mm)	0.636 ± 0.010	0.592 ± 0.014^a	0.633 ± 0.023	0.616 ± 0.016

Average results ± standard error; per group; ^a, ^aa, and ^aaa compared to sham.