XRCC5 VNTR, XRCC6 -61C>G, and XRCC7 6721G>T Gene Polymorphisms Associated with Male Infertility Risk: Evidences from Case-Control and In Silico Studies
Table 3
Genotype and allele frequencies of XRCC6 and XRCC7 gene polymorphisms in controls and infertile patients.
Genotype
Control
Patients
value [OR (95% CI )]
Study power %a
Total () n (%)
Total () n (%)
AS () n (%)
Severe OS () n (%)
Controls versus total patients
Controls versus AS
Controls versus severe OS
Controls versus total patients
Controls versus AS
Controls versus severe OS
XRCC6 -61C>G
CC
118 (55.14)
79 (44.38)
37 (36.27)
42 (55.26)
52.31
86.09
1.772
CG
75 (35.04)
62 (34.83)
44 (43.13)
18 (23.68)
0.348 [1.234 (0.794–1.918)]
0.019 [1.871 (1.107–3.160)]
0.215 [0.674 (0.361–1.257)]
1.965
24.35
38.06
GG
21 (9.81)
37 (20.78)
21 (20.58)
16 (21.05)
0.001 [2.631 (1.434–4.827)]
0.001 [3.189 (1.570–6.478)]
0.043 [2.140 (1.021–4.484)]
82.26
67.33
62.16
CG + GG
96 (44.85)
99 (55.61)
65 (63.72)
34 (44.73)
0.034 [1.540 (1.032–2.297)]
0.001 [2.159 (1.329–3.508)]
0.985 [0.995 (0.587–1.684)]
52.31
86.09
1.772
C
311 (72.66)
220 (61.79)
118 (57.84)
102 (67.10)
58.73
70.27
11.98
G
117 (27.33)
136 (38.20)
86 (42.15)
50 (32.89)
0.001 [1.643 (1.215–2.221)]
0.0002 [1.937 (1.3653–2.748)]
0.194 [1.303 (0.873–1.943)]
58.74
70.28
11.98
XRCC7 6721G>T
GG
21 (9.81)
17 (9.55)
6 (5.88)
11 (36.84)
2.619
13.07
99.72
GT
104 (48.59)
74 (41.57)
41 (40.19)
33 (34.21)
0.720 [0.879 (0.434–1.779)]
0.518 [1.379 (0.519–3.664)]
0.235 [0.605 (0.264–1.386)]
24.88
24.45
52.76
TT
89 (41.58)
87 (48.87)
55 (53.92)
32 (28.94)
0.599 [1.207 (0.597–2.442)]
0.118 [2.162 (0.821–5.691)]
0.376 [0.686 (0.298–1.580)]
26.71
49
43.56
GT + TT
193 (90.18)
161 (90.44)
96 (94.11)
65 (63.15)
0.930 [1.030 (0.525–2.019)]
0.247 [1.740 (0.680–4.455)]
0.268 [0.643 (0.294–1.405)]
2.618
13.07
99.72
G
146 (34.11)
108 (30.33)
53 (25.98)
55 (36.18)
9.847
7.13
2.466
T
282 (65.88)
248 (69.66)
151 (74.01)
97 (63.81)
0.207 [1.213 (0.8981–1.639)]
0.030 [1.505 (1.039–2.180)]
0.719 [0.931 (0.633–1.370)]
9.847
7.129
2.466
aPower based on normal approximation with continuity correction.
