The Tissue-Selective Estrogen Complex (Bazedoxifene/Conjugated Estrogens) for the Treatment of Menopause

Table 1

Targeted responses to systemic menopause treatments [6–11].

Target	SERMs; Ral, BZA	Estrogen	STEAR; (tibolone)	TSEC; (BZA/CE)
Uterus	0	−	=	0
Hot flushes	−	+	+	+
Vagina	−	+	+	+
Bone	+	+	+	+
Breast	+	0	=	0
Sexual function	=	+	++	+
Energy levels	=	+	++	+

STERM: selective estrogen receptor modulator; Ral: raloxifene; BZA: bazedoxifene; STEAR: selective tissue estrogenic activity regulator (tibolone); TSEC: tissue selective estrogen complex = BZA + CE; +: positive effect; ++: very positive effect; −: negative effect; =: neutral effect.