International Journal of Endocrinology / 2017 / Article / Tab 3 / Review Article
The Tissue-Selective Estrogen Complex (Bazedoxifene/Conjugated Estrogens) for the Treatment of Menopause Table 3 Preclinical studies on endometrial tissue.
Model Results Peano et al. [26 ] Ovariectomized mice (i) BZA, in contrast to RLX or LAS, antagonized the increase in uterine wet weight to levels similar to that induced by vehicle Oliva et al. [28 ] Ovariectomized mitosis—luciferase mice (i) BZA and CE completely inhibited the proliferative effects of CE in the uterus Kharode et al. [29 ] Ovariectomized rats (i) BZA/CE inhibited CE-induced uterine stimulation Komm and Lyttle [22 ] Ovariectomized rats (i) BZA/CE reduced CE-induced uterine wet weight increase in a dose-dependent manner Ethun et al. [30 ] Ovariectomized cynomolgus macaques (i) Endometrial and epithelial proliferations were significantly reduced with BZA/CE in comparison with CE alone ( ) (ii) Endometrial hyperplasia rate following BZA/CE treatment was comparable to controls