The Associations of Serum Uric Acid with Obesity-Related Acanthosis nigricans and Related Metabolic Indices
Table 1
General anthropometric and metabolic characteristics of the study cohort divided by females and males.
Parameters
Female ()
Male ()
OB ()
AN ()
OB ()
AN ()
UA (μmol/L)
344.2 ± 65.1
407.8 ± 89.1
<0.001
430.6 ± 82.4
496.3 ± 112.5
<0.001
Age (yr)
31 (12)
26 (12)
<0.001
30 (10)
24 (14)
<0.001
Weight (kg)
81.77 ± 11.43
95.15 ± 15.23
<0.001
106.52 ± 14.79
114.42 ± 20.04
0.002
BMI (kg/m2)
30.99 ± 3.52
35.10 ± 5.04
<0.001
34.29 ± 3.96
36.79 ± 5.22
0.002
Waist circumference (cm)
99.46 ± 9.49
109.99 ± 12.62
<0.001
112.51 ± 10.46
117.03 ± 11.63
0.011
Waist/hip ratio
0.916 ± 0.069
0.960 ± 0.062
<0.001
0.987 ± 0.059
0.998 ± 0.044
0.137
Percentage of body fat (%)
36.98 ± 3.41
38.68 ± 4.38
0.002
31.88 ± 5.21
32.72 ± 4.99
0.940
SBP (mmHg)
128 ± 17
135 ± 15
0.006
133 ± 14
140 ± 14
0.001
DBP (mmHg)
83 ± 10
87 ± 11
0.014
83 ± 11
85 ± 11
0.305
Cr (μmol/L)
56.88 ± 7.36
56.82 ± 8.88
0.964
74.95 ± 13.71
74.28 ± 13.29
0.760
ALT (U/L)
32.72 ± 26.97
56.96 ± 41.55
<0.001
61.73 ± 56.21
85.08 ± 58.03
<0.001
AST (U/L)
25.19 ± 14.06
34.77 ± 20.29
<0.001
33.92 ± 27.96
43.84 ± 24.35
<0.001
TC (mmol/L)
5.02 ± 1.12
4.86 ± 0.93
0.473
4.93 ± 0.95
4.97 ± 1.00
0.774
TG (mmol/L)
1.64 ± 0.99
2.03 ± 2.49
0.399
2.02 ± 1.17
1.79 ± 0.83
0.207
HDL (mmol/L)
1.16 ± 0.26
1.13 ± 0.49
0.056
1.04 ± 0.19
0.97 ± 0.19
0.015
LDL (mmol/L)
3.08 ± 1.01
2.97 ± 0.86
0.650
3.09 ± 0.83
3.22 ± 0.85
0.307
BG0 (mmol/L)
5.41 ± 1.09
5.77 ± 1.70
0.079
5.81 ± 2.19
5.38 ± 1.10
0.471
INS0 (mU/L)
23.91 ± 21.40
34.12 ± 17.91
<0.001
25.64 ± 18.48
39.66 ± 31.74
<0.001
CP0 (ng/mL)
3.37 ± 1.28
4.42 ± 1.30
<0.001
3.68 ± 1.43
4.75 ± 1.82
<0.001
HOMA-IRa
1.54 ± 0.64
2.01 ± 0.61
<0.001
1.67 ± 0.70
2.04 ± 0.65
<0.001
Data are expressed as mean ± SD or median (interquartile range); versus OB, ; ; ; athe data was ln-transformed to normality before analysis. AN: obese group with Acanthosis nigricans; OB: simple obese group; BMI: body mass index; SBP: systolic blood pressure; DBP: diastolic blood pressure; UA: uric acid; Cr: serum creatinine; ALT: alanine transaminase; AST: aspertate aminotransferase; TC: total cholesterol; TG: triglyceride; HDL: high-density lipoprotein; LDL: low-density lipoprotein; BG0: 0 min glucose; INS0: 0 min insulin; CP0: 0 min C peptide; HOMA-IR: homeostasis assessment model of insulin resistance.
