Clinicopathological Characteristics and Prognosis of Papillary Thyroid Carcinoma in Naturally Menopausal Women with Various Durations of Premenarche, Reproductive Periods, and Postmenopausal Stages
Table 2
Clinicopathological characteristics, treatment modalities, and outcome characteristics of PTC patients at various menstrual stages.
Variables
Total ()
Total ()
Total ()
Age at menarche, years
Pa for trend
Length of reproductive life, years
Pa for trend
Years after menopause, years
Pa for trend
Group 1 (): <14
Group 2 (): 14–16
Group 3 (): >16
Group 1 (): <30
Group 2 (): 30–38
Group 3 (): >38
Group 1 (): <4
Group 2 (): 4–14
Group 3 (): >14
Age (mean, range)
55.8 (37–78)
58.6 (42–80)
56.9 (47–74)
NS
54.2 (37–74)
57.9 (46–78)
60.7 (54–80)
0.00
51.8 (46–70)
56.3 (46–78)
66.7 (46–77)
0.00
Age at first birth (mean, range)
24.1 (16–33)
24.3 (16–35)
25.1 (18–35)
NS
23.0 (16–34)
24.6 (16–35)
24.8 (16–34)
NS
23.4 (16–35)
24.8 (16–35)
24.7 (16–35)
0.04
Age at last birth (mean, range)
29.2 (18–36)
29.8 (17–44)
30.7 (21–43)
NS
27.9 (17–39)
30.2 (17–44)
29.8 (18–42)
0.03
29.1 (17–41)
30.1 (18–43)
30.5 (17–44)
NS
Maximal tumor diameter
≤1 (cm) >1 (cm)
27 10
194 97
70 31
NS
26 13
229 108
36 17
NS
68 26
156 69
67 43
NS
Multicentricity
Solitary Multiple
23 14
199 92
65 36
NS
23 16
230 107
34 19
NS
69 25
154 71
64 46
0.02
Bilaterality
Unilateral Bilateral
29 8
225 66
75 26
NS
30 9
262 75
37 16
NS
77 17
172 53
80 30
NS
Extrathyroidal extension
Present Absent
9 28
127 164
42 59
NS
13 26
149 188
16 37
NS
34 60
92 133
52 58
NS
Intrathyroidal dissemination
Present Absent
2 35
15 276
6 95
NS
5 34
15 322
3 50
NS
2 92
10 215
11 99
0.01
Thyroid nodular goiter
Present Absent
22 15
173 118
58 43
NS
17 22
205 132
31 22
NS
54 40
136 89
63 47
NS
Hashimoto’s thyroiditis
Present Absent
3 34
9 282
6 95
NS
2 37
15 322
1 52
NS
7 87
10 215
1 109
NS
TNM stage
I
23
173
59
NS
27
198
30
NS
58
135
62
NS
II
1
10
2
NS
1
9
2
NS
2
6
4
NS
III
8
57
18
NS
8
66
10
NS
17
45
22
NS
IV
5
51
22
NS
3
64
11
NS
17
39
22
NS
T staging
T1
29
225
83
NS
32
263
42
NS
79
180
78
NS
T2
2
22
3
NS
1
22
4
NS
6
12
9
NS
T3
4
32
8
NS
6
35
3
NS
9
20
15
NS
T4
2
12
7
NS
0
17
4
NS
0
13
8
NS
N staging
N0/Nx
25
197
62
NS
28
221
35
NS
63
149
72
NS
N1a
9
55
21
NS
7
66
12
NS
16
50
19
NS
N1b
3
39
18
NS
4
50
6
NS
15
26
19
NS
M staging
M0
37
287
101
NS
39
334
52
NS
93
224
108
NS
M1
0
4
0
0
3
1
1
1
2
Operation of primary tumor
Total thyroidectomy
11
101
43
NS
18
117
20
NS
32
80
43
NS
Subtotal thyroidectomy
26
190
58
21
220
33
62
167
67
Lymph node dissection
Not done
3
39
9
NS
6
39
6
NS
12
34
15
NS
Central node dissection
27
200
73
NS
29
232
39
NS
63
188
70
NS
Total node dissection
7
52
19
NS
4
66
8
NS
19
38
25
NS
Iodine radiotherapy
Done Not done
6 31
31 260
12 89
NS
5 34
37 300
7 46
NS
12 82
24 201
13 97
NS
Recurrence of disease
Present Absent
2 35
11 280
4 97
NS
4 35
8 329
5 48
NS
0 94
10 215
7 103
0.02
Disease-specific survival (DSS)
Dead Alive
1 36
2 289
0 101
NS
1 38
1 336
1 52
NS
0 94
1 224
2 107
NS
aANOVA for continuous variables and chi-square test for categorical variables. NS: not significant. Bold values are less than or close to 0.05.
