Clinicopathological Characteristics and Prognosis of Papillary Thyroid Carcinoma in Naturally Menopausal Women with Various Durations of Premenarche, Reproductive Periods, and Postmenopausal Stages
Table 3
Clinicopathological characteristics, treatment modalities, and outcome characteristics of PTMC patients at various menstrual stages.
Variables
Total ()
Total ()
Total ()
Age at menarche, years
Pa for trend
Length of menstrual life, years
Pa for trend
Years after menopause, years
Pa for trend
Group 1 (): <14
Group 2 (): 14–16
Group 3 (): >16
Group 1 (): <30
Group 2 (): 30–38
Group 3 (): >38
Group 1 (): <4
Group 2 (): 4–14
Group 3 (): >14
Age (mean, range)
54.9 (37–68)
57.9 (44–77)
56.8 (45–74)
NS
55.3 (37–72)
57.3 (46–77)
59.6 (55–70)
0.02
52.1 (44–63)
56.3 (37–68)
65.3 (55–77)
0.00
Age at first birth (mean, range)
24.5 (16–33)
24.1 (16–35)
24.6 (18–35)
NS
22.8 (16–32)
24.4 (16–35)
24.8 (16–34)
NS
23.3 (16–35)
24.6 (16–35)
24.7 (16–35)
NS
Age at last birth (mean, range)
29.9 (18–36)
29.4 (17–42)
30.1 (21–43)
NS
27.2 (17–37)
29.8 (17–43)
30.2 (18–42)
NS
29.0 (17–40)
29.6 (18–43)
30.3 (17–41)
NS
Multicentricity
Solitary Multiple
17 10
140 54
47 23
NS
14 12
165 64
25 11
NS
52 16
110 46
42 25
0.02
Bilaterality
Unilateral Bilateral
22 5
160 34
55 15
NS
21 5
190 39
26 10
NS
58 10
126 30
53 14
NS
Extrathyroidal extension
Present Absent
7 20
52 142
21 49
NS
5 21
69 160
6 30
NS
18 50
45 111
17 50
NS
Intrathyroidal dissemination
Present Absent
1 26
4 190
2 68
NS
1 25
6 223
0 36
NS
0 68
5 151
2 65
NS
Thyroid nodular goiter
Present Absent
19 8
125 69
44 26
NS
13 13
153 76
22 14
NS
46 22
99 57
43 24
NS
Hashimoto’s thyroiditis
Present Absent
1 26
8 186
4 66
NS
1 25
11 218
1 35
NS
5 63
7 149
1 66
NS
TNM stage
I
20
154
49
NS
22
174
27
NS
53
114
56
NS
II
0
0
0
NS
0
0
0
NS
0
0
0
NS
III
7
28
13
NS
3
39
6
NS
10
32
6
NS
IV
0
12
8
NS
1
16
3
NS
5
10
5
NS
T staging
T1
26
187
70
NS
26
221
36
NS
68
149
66
NS
T2
0
0
0
NS
0
0
0
NS
0
0
0
NS
T3
1
6
0
NS
0
7
0
NS
0
7
0
NS
T4
0
1
0
NS
0
1
0
NS
0
0
1
NS
N staging
N0/Nx
20
157
50
NS
22
177
28
NS
54
117
56
NS
N1a
7
27
13
NS
3
37
7
NS
10
31
6
NS
N1b
0
10
7
NS
1
15
1
NS
4
8
5
NS
M staging
M0
27
193
70
NS
26
229
35
NS
68
155
67
NS
M1
0
1
0
0
0
1
0
1
0
Operation of primary tumor
Total thyroidectomy
6
54
25
NS
10
64
11
NS
23
42
47
NS
Subtotal thyroidectomy
21
140
45
16
165
25
45
114
20
Lymph node dissection
Not done
2
31
9
NS
4
34
4
NS
12
20
10
NS
Central node dissection
22
148
53
NS
21
173
29
NS
51
122
50
NS
Total node dissection
3
15
8
NS
1
22
3
NS
5
14
7
NS
Iodine radiotherapy
Done Not done
2 25
7 187
2 68
NS
1 25
8 221
2 34
NS
2 66
6 150
3 64
NS
Recurrence of disease
Present Absent
1 26
5 189
4 66
NS
3 23
5 224
2 34
NS
0 68
8 148
2 65
NS
Disease-specific survival (DSS)
Dead Alive
0 27
1 193
0 70
NS
1 25
0 229
0 36
NS
0 68
0 156
1 66
NS
aANOVA for continuous variables and chi-square test for categorical variables. NS: not significant. Bold values are less than or close to 0.05.
