Clinicopathological Characteristics and Prognosis of Papillary Thyroid Carcinoma in Naturally Menopausal Women with Various Durations of Premenarche, Reproductive Periods, and Postmenopausal Stages

Table 4

Univariate and multivariable-adjusted HRs (95% CI) of recurrence according to multicentricity, intrathyroidal dissemination, various menstrual stages, and time of pregnancy.

PTC

PTMC

Variables

Recurrence; of disease: present/absent

Univariate HR

95% CI

P

P^trend

Multivariate; HR

95% CI

P

P^trend

Recurrence; of disease: present/absent

Univariate; HR

95% CI

P

P^trend

Multivariate; HR (††)

95% CI

P

P^trend

Multicentricity

Solitary; Multiple

11/318; 6/94

1.8

0.7–4.9

NS

NS

^a1.6

0.5–5.5

NS

NS

9/228; 1/53

0.5

0.1–4.2

NS

NS

^a0.5

0.1–5.0

NS

NS

Intrathyroidal; dissemination

Absent; Present

9/242; 8/170

1.2

0.5–3.2

NS

NS

^b1.1

0.4–3.1

NS

NS

6/205; 4/76

1.7

0.5–6.2

NS

NS

^b2.8

0.7–12.6

NS

NS

Age at; menarche; (years)

<14

2/35

2.0

0.5–9.7

NS

^c1.3

0.2–7.6

NS

1/26

1.7

0.2–14.3

NS

^c1.7

0.2–14.3

NS

14–16

11/280

1

Reference

NS

NS

^c1

Reference

NS

NS

5/189

1

Reference

NS

NS

^c1

Reference

NS

NS

>16

4/97

2.3

0.7–7.1

NS

^c2.8

0.7–11.6

NS

4/66

4.5

1.2–16.9

0.02

^c4.5

1.2–16.9

0.02

Length of; reproductive; life (years)

<30

4/35

3.4

1.0–11.3

0.02

^d4.2

1.2–13.9

0.00

3/23

4.4

1.1–18.7

NS

^d4.3

0.8–23.1

NS

30–38

8/329

1

Reference

0.04

NS

^d1

Reference

0.02

NS

5/224

1

Reference

0.03

NS

^d1

Reference

NS

NS

>38

5/48

4.6

1.5–13.9

0.01

^d5.6

1.7–17.2

0.00

2/34

2.7

0.5–14.0

NS

^d2.2

0.4–13.8

NS

Years after; menopause

<4

0/77

0.2

0.0–1.7

NS

^e0.3

0.0–2.9

NS

0/52

0.0

0.0–1.8

NS

^e0.0

0.0–4.2

NS

4–14

11/243

1

Reference

NS

NS

^e1

Reference

NS

NS

8/176

1

Reference

NS

NS

^e1

Reference

NS

NS

>14

6/92

0.9

0.3–2.5

NS

^e0.4

0.07–2.5

NS

2/53

1.0

0.2–3.7

NS

^e0.8

0.1–4.6

NS

Age at first; birth

<21

3/75

1.0

0.2–4.3

NS

^f1.0

0.2–4.2

NS

2/57

1.0

0.7–1.5

NS

^f1.1

0.7–1.6

NS

21–28

9/241

1

Reference

NS

NS

^f1

Reference

NS

NS

6/161

1

Reference

NS

NS

^f1

Reference

NS

NS

>28

5/96

1.5

0.3–6.4

NS

^f1.4

0.3–6.8

NS

2/63

1.2

0.8–1.7

NS

^f1.2

0.7–1.9

NS

Age at last; birth

<26

4/91

1.3

0.3–5.1

NS

^g1.4

0.3–5.6

NS

3/70

0.9

0.6–1.3

NS

^g0.9

0.6–1.4

NS

26–34

9/238

1

Reference

NS

NS

^g1

Reference

NS

NS

5/161

1

Reference

NS

NS

^g1

Reference

NS

NS

>34

4/83

1.0

0.4–4.4

NS

^g1.2

0.2–6.1

NS

2/50

1.0

0.7–1.5

NS

^g0.9

0.6–1.5

NS

PTC: papillary thyroid carcinoma; PTMC: papillary thyroid microcarcinoma; HR: hazard ratio; CIs: confidence intervals; P: value for each variable; P^trend: value for the trend. Adjusted for age, TNM stages, tumor size (except for ††), bilaterality, thyroid nodular goiter, Hashimoto’s thyroiditis, surgery for primary tumor, lymph node dissection, multicentricity (except for a), intrathyroidal dissemination (except for b), age at menarche (except for c), length of reproductive span (except for d), years after menopause (except for e), age at first birth (except for f), and age at last birth (except for g).