PDE5 Overexpression in Well-Differentiated Thyroid Carcinomas Is Associated with Lymph Node Metastasis

Table 2

Correlation between PDE5 expression and clinicopathological features.

Clinicopathological parameters		Total	The level of PDE5 expression		value
			High (%)	Low (%)
Gender	Male	36	19 (36.5)	17 (33.3)	0.733
	Female	67	33 (63.5)	34 (66.7)
Age (years)	<45	67	39 (75.0)	28 (54.9)	0.032
	≥45	36	13 (25.0)	23 (45.1)
Histological type	PTC	100	51 (98.1)	49 (96.1)	0.618
	FTC	3	1 (1.9)	2 (3.9)
Focus	Single	58	30 (57.7)	28 (54.9)	0.774
	Multiple	43	21 (42.3)	22 (45.1)
Invasion of capsule or ETE	No	89	45 (86.5)	44 (86.3)	0.969
	Yes	14	7 (13.5)	7 (13.7)
Distant metastasis	M0	84	47 (90.4)	37 (72.5)	0.020
	M1	19	5 (9.6)	14 (27.5)
LN involvement	N0	46	16 (30.8)	30 (58.8)	0.004
	N1	57	36 (69.2)	21 (41.2)	OR = 2.79

ETE: extracapsular extension; PTC: papillary thyroid cancer; FTC: follicular thyroid cancer.