Prolonged Survival of Subcutaneous Allogeneic Islet Graft by Donor Chimerism without Immunosuppressive Treatment

Figure 2

Kaplan-Meier plot of cumulative cure rate of diabetes. Diabetic mice in both groups A and B received conditioning and BMC transplantation. The mice in group A received 300 allogeneic islets under the left kidney subcapsular space, and the mice in group B received 900 allogeneic islets under the subcutaneous space of the back. After islet transplantation, nonfasting whole blood glucose levels of the recipients were determined twice weekly, and the cure of diabetes was defined as a whole blood glucose level below 200 mg/dL for two consecutive tests and thereafter. The difference in cumulative cure rate of diabetes between two the groups was analyzed with the log-rank test, and the value of the comparison was <0.05.