Prolonged Survival of Subcutaneous Allogeneic Islet Graft by Donor Chimerism without Immunosuppressive Treatment

Figure 4

The effect of donor chimerism on blood glucose and body weight changes in the mice. All mice in groups A and C received 300 allogeneic islets under the left kidney subcapsular space. The mice in group A received conditioning and BMC transplantation, whereas the mice in group C received conditioning but no BMC infusion. The nonfasting whole blood glucose level (a) and body weight (b) of the mice in groups A and C were determined twice weekly. All mice in groups B and D received 900 allogeneic islets under the subcutaneous space of the back. The mice in group B received conditioning and BMC transplantation, whereas the mice in group D received conditioning and transplantation of both BMCs and MSCs. The nonfasting whole blood glucose level (c) and body weight (d) of the mice in groups B and D were determined twice weekly.

(a)

(b)

(c)

(d)