Prolonged Survival of Subcutaneous Allogeneic Islet Graft by Donor Chimerism without Immunosuppressive Treatment

Table 2

Population of different cells developed in the peripheral blood of mice that received conditioning and bone marrow cell and/or mesenchymal stem cell transplantation.

Cell population (%)	Group A; Renal site; ()		Group B; Subcutaneous site; ()		Group D; Subcutaneous site; ()
Time	2 weeks	8 weeks	2 weeks	8 weeks	2 weeks	8 weeks
CD4	2.8 ± 1.0	9.7 ± 1.9	2.3 ± 1.3^i	7.1 ± 2.8^o	15.2 ± 2.8^i	17.9 ± 1.6^o
CD8	8.5 ± 1.9	3.6 ± 0.5	5.9 ± 1.0	4.5 ± 0.7	6.8 ± 1.8	6.3 ± 0.8
CD45	93.1 ± 1.5	92.8 ± 1.8	91.9 ± 1.0	89.8 ± 1.9	88.9 ± 1.3	98.2 ± 0.3
CD11b	83.4 ± 1.5	48.3 ± 6.6	85.7 ± 2.8^j	53.3 ± 14.7	57.4 ± 2.7^j	44.6 ± 4.9
CD11c	9.0 ± 2.2^a,b	6.2 ± 1.1^e,f	3.9 ± 0.6^a,k	1.1 ± 0.2^e,p	11.8 ± 4.3^b,k	9.6 ± 2.5^f,p
CD19	1.1 ± 0.2^c	15.7 ± 2.3^g	5.8 ± 1.7^l	17.7 ± 5.5	15.7 ± 4.7^c,l	19.9 ± 4.9^g
Gr1	81.2 ± 1.5	45.1 ± 6.8	81.1 ± 3.3^m	49.9 ± 15.4	61.6 ± 5.1^m	54.0 ± 5.0
Foxp3	4.9 ± 0.8^d	6.5 ± .0.5^h	5.3 ± 1.2^n	5.9 ± 1.2^q	10.4 ± 1.9^d,n	10.7 ± 0.6^h,q

The mean frequency of different cells in the venous blood was measured by flow cytometry at 2 and 8 weeks posttransplantation. ^a,b,f,g,l,n, ^d,e,h,k,o,p, ^i,m,q, and ^c,j comparing the two means using independent t-tests.