Prolonged Survival of Subcutaneous Allogeneic Islet Graft by Donor Chimerism without Immunosuppressive Treatment
Table 3
T cell subsets were identified by flow cytometry analysis.
T subset (%)
Group A Renal site ()
Group B Subcutaneous site ()
Group D Subcutaneous site ()
Time
2 weeks
8 weeks
2 weeks
8 weeks
2 weeks
8 weeks
CD4-TN
31.1 ± 5.4
66.5 ± 9.2
38.4 ± 11.3
59.6 ± 15.9
60.8 ± 7.9
31.2 ± 9.5
CD4-TEM
37.7 ± 5.5
14.6 ± 8.9
35.8 ± 8.6a
24.6 ± 13.8
12.0 ± 3.8a
15.3 ± 1.9
CD4-TCM
5.5 ± 1.0
9.9 ± 1.5
5.6 ± 1.0
9.1 ± 1.6
8.7 ± 1.0
9.2 ± 2.5
CD8-TN
1.4 ± 0.3
47.4 ± 9.5
3.4 ± 1.5b
34.4 ± 15.9
15.7 ± 2.8b
12.4 ± 4.3
CD8-TEM
90.7 ± 0.9
29.6 ± 9.4
86.0 ± 1.9c
49.9 ± 17.2
41.9 ± 6.1c
31.8 ± 3.8
CD8-TCM
4.3 ± 0.4
16.0 ± 1.5
7.9 ± 1.2d
13.9 ± 2.4
21.7 ± 3.5d
22.2 ± 3.3
Naive T cells (TN), central memory T cells (TCM), and effector memory T cells (TEM) were defined as CD44loCD62L+, CD44hiCD62L+, and CD44hiCD62L−, respectively. a, b, c, and d comparing the indicated two means using independent t-test.