Hydrogen Sulfide Inhibits High Glucose-Induced sFlt-1 Production via Decreasing ADAM17 Expression in 3T3-L1 Adipocytes

Figure 6

Effects of NaHS on high glucose-induced upregulation of ADAM17 expression and sFlt-1 production in 3T3-L1 adipocytes. 3T3-L1 adipocytes were treated with HG DMEM containing increasing concentration of NaHS for 24 h. (a and b) The effects of NaHS on high glucose-induced upregulation of ADAM17 expression. The protein expression of ADAM17 in 3T3-L1 adipocytes was determined by Western blotting. Representative protein bands were presented on the top of the corresponding histogram. (c) The effects of NaHS on high glucose-induced upregulation of sFlt-1 production in 3T3-L1 adipocytes. The production of sFlt-1 in the media was measured by ELISA. Data were presented as mean ± SEM ( cultures). , versus indicated.

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