Research Article
Clinicopathological and Survival Outcomes of Well-Differentiated Thyroid Carcinoma Undergoing Dedifferentiation: A Retrospective Study from FUSCC
Table 2
Risk factors for decreased cause-specific survival in WDTC patients harboring dedifferentiated phenotype.
| Variables | Univariate analysis | Multivariate analysis | value | HR | 95.0% CI for HR | value | HR | 95.0% CI for HR |
| Gender | | | | | | | Female | | 1 | | | | | Male | 0.134 | 1.977 | 0.810–4.822 | | | | Age | 0.013 | 1.041 | 1.009–1.076 | 0.488 | 1.014 | 0.974–1.056 | Maximum size | 0.113 | 1.233 | 0.952–1.597 | | | | ETE | | | | | | | No | | 1 | | | | | Yes | 0.396 | 0.620 | 0.205–1.870 | | | | Histological subtypes of WDTC | | | | | | | FTC | | 1 | | | | | PTC | 0.251 | 2.352 | 0.545–10.144 | | | | Dedifferentiated site | | | | | | | Thyroid | | 1 | | | 1 | | Metastatic site | 0.052 | 2.531 | 0.992–6.458 | 0.337 | 1.656 | 0.592–4.633 | Thyroid and metastatic site | 0.052 | 3.805 | 0.991–14.609 | 0.642 | 1.510 | 0.266–8.569 | Dedifferentiated components | | | | | | | PDTC | | 1 | | | 1 | | ATC | 0.011 | 3.227 | 1.308–7.961 | 0.033 | 3.732 | 1.116–12.478 | LNM | | | | | | | No | | 1 | | | | | Yes | 0.322 | 1.669 | 0.606–4.4598 | | | | DM | | | | | | | No | | 1 | | | 1 | | Yes | 0.056 | 2.421 | 0.976–6.005 | 0.367 | 1.707 | 0.534–5.463 | Adjuvant therapy | | | | | | | No | | 1 | | | 1 | | Yes | 0.016 | 3.035 | 1.277–7.508 | 0.046 | 2.715 | 1.017–7.249 |
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Bold type indicates statistical significance. WDTC: well-differentiated thyroid cancer; HR: hazard ratio; CI: confidence interval; ETE: extrathyroidal extension; FTC: follicular thyroid cancer; PTC: papillary thyroid cancer; PDTC: poorly differentiated thyroid cancer; ATC: anaplastic thyroid cancer; LNM: lymph node metastasis; DM: distant metastasis.
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