Research Article
Clinicopathological and Survival Outcomes of Well-Differentiated Thyroid Carcinoma Undergoing Dedifferentiation: A Retrospective Study from FUSCC
Table 3
Risk factors for decreased disease-free survival in WDTC patients harboring dedifferentiated phenotype.
| Variables | Univariate analysis | Multivariate analysis | value | HR | 95.0% CI for HR | value | HR | 95.0% CI for HR |
| Gender | | | | | | | Female | | 1 | | | | | Male | 0.145 | 1.805 | 0.816–3.992 | | | | Age | 0.002 | 1.045 | 1.016–1.076 | 0.015 | 1.038 | 1.007–1.070 | Maximum size | 0.351 | 1.105 | 0.896–1.364 | | | | ETE | | | | | | | No | | 1 | | | | | Yes | 0.630 | 1.240 | 0.517–2.977 | | | | Histological subtypes of WDTC | | | | | | | FTC | | 1 | | | | | PTC | 0.150 | 2.893 | 0.682–12.278 | | | | Dedifferentiated site | | | | | | | Thyroid | | 1 | | | 1 | | Metastatic site | 0.016 | 2.746 | 1.210–6.235 | 0.559 | 1.312 | 0.528–3.259 | Thyroid and metastatic site | 0.250 | 2.437 | 0.534–11.109 | 0.668 | 1.408 | 0.296–6.706 | Dedifferentiated components | | | | | | | PDTC | | 1 | | | | | ATC | 0.137 | 1.941 | 0.809–4.658 | | | | LNM | | | | | | | No | | 1 | | | | | Yes | 0.092 | 2.323 | 0.871–6.197 | | | | DM | | | | | | | No | | 1 | | | | | Yes | 0.003 | 3.358 | 1.517–7.432 | 0.128 | 1.914 | 0.829–4.417 | Adjuvant therapy | | | | | | | No | | 1 | | | | | Yes | 0.054 | 2.249 | 0.987–5.126 | | | |
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Bold type indicates statistical significance. WDTC: well-differentiated thyroid cancer; HR: hazard ratio; CI: confidence interval; ETE: extrathyroidal extension; FTC: follicular thyroid cancer; PTC: papillary thyroid cancer; PDTC: poorly differentiated thyroid cancer; ATC: anaplastic thyroid cancer; LNM: lymph node metastasis; DM: distant metastasis.
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