GH, IGF-1, and Age Are Important Contributors to Thyroid Abnormalities in Patients with Acromegaly

Table 1

Comparisons of demographical and clinical characteristics between groups divided by median random GH, nadir GH, and IGF-1.

	Random GH ()			Nadir GH ()			IGF-1 ()
	Group I	Group II	value	Group I	Group II	value	Group I	Group II	value
Sex (n, %)
Male (n)	20 (46.5)	20 (46.5)	0.369	19 (44.2)	21 (48.8)	0.665	10 (23.3)	14 (32.6)	0.336
Female (n)	23 (53.5)	23 (53.5)		24 (55.8)	22 (51.2)		33 (76.7)	29 (67.4)
Age (years)	39.53 ± 12.70	41.58 ± 12.27	0.449	39.07 ± 12.91	42.05 ± 11.95	0.27	40.37 ± 12.71	40.16 ± 12.48	0.939
Thyroid volume (cm^3)	19.14 ± 7.98	27.97 ± 16.16	0.010	19.31 ± 8.56	28.41 ± 16.20	0.008	19.37 ± 8.46	27.45 ± 16.13	0.018
(Multiple linear regression)			0.002			0.005			0.004
TSH (μIU/ml)	1.52 ± 0.92	1.43 ± 1.44	0.743	1.53 ± 0.92	1.43 ± 1.44	0.711	1.66 ± 1.38	1.34 ± 1.02	0.234
T3 (ng/ml)	0.96 ± 0.31	1.04 ± 0.31	0.244	0.98 ± 0.31	1.02 ± 0.32	0.592	0.91 ± 0.28	1.09 ± 0.31	0.010
(Multiple linear regression)									0.044
T4 (μg/dl)	8.77 ± 1.99	8.86 ± 2.08	0.847	8.81 ± 1.97	8.82 ± 2.11	0.978	8.25 ± 1.03	9.32 ± 1.89	0.018
FT3 (pg/ml)	2.89 ± 0.68	2.85 ± 0.66	0.256	2.91 ± 0.64	2.82 ± 0.70	0.559	2.63 ± 0.59	3.06 ± 0.72	0.004
FT4 (ng/dl)	1.21 ± 0.25	1.15 ± 0.20	0.232	1.22 ± 0.25	1.13 ± 0.20	0.108	1.15 ± 0.26	1.20 ± 0.18	0.272

values less than 0.05; values less than 0.01.