GH, IGF-1, and Age Are Important Contributors to Thyroid Abnormalities in Patients with Acromegaly

Table 2

Risk factors of thyroid abnormalities in patients with acromegaly.

	Patients with normal thyroid ()	Patients with thyroid abnormalities ()	value	Binary logistic regression analysis
				OR (95% CI)	value
Sex (n, %)
Male	28 (38.9)	12 (57.1)	0.137	0.628 (0.198–1.992)	0.249
Female	44 (61.1)	9 (42.9)
Age (years)	44.38 ± 12.51	31.48 ± 8.87	<0.001	1.092 (1.034–1.154)	0.002
Acromegaly duration (months)	60 (20, 114)	36 (18, 66)	0.089	1.002 (0.992–1.013)	0.661
Pituitary adenoma volume (cm^3)	1.15 (0.34, 2.66)	2.26 (0.71, 5.68)	0.223	1.027 (0.810–1.301)	0.828
Thyroid volume (cm^3)	24.32 ± 14.16	20.36 ± 8.56	0.284	1.028 (0.959–1.102)	0.432
BMI (kg/m^2)	27.08 ± 3.94	25.56 ± 4.16	0.136	1.122 (0.944–1.335)	0.192
TSH (μIU/ml)	1.63 ± 1.47	1.36 ± 0.93	0.433	N/A	N/A
T3 (ng/ml)	0.99 ± 0.31	1.02 ± 0.29	0.781	N/A	N/A
T4 (μg/dl)	8.86 ± 2.07	8.33 ± 1.76	0.303	N/A	N/A
Random GH (ng/ml)	15.25 (8.60, 52.50)	12.0 (7.30, 33.95)	0.212	1.013 (0.996–1.029)	0.127
Nadir GH (ng/ml)	10.45 (5.70, 38.30)	7.04 (4.94, 22.03)	0.194	1.014 (0.996–1.032)	0.135
IGF-1 (ng/ml)	849.65 ± 310.01	822.16 ± 214.02	0.719	1.001 (0.999–1.003)	0.393
GH burden (months ng/ml)	1321.8 (313.2, 3360.0)	463.8 (187.2, 1180.0)	0.036	1.000 (1.000–1.001)	0.090

values less than 0.05; values less than 0.01.