Research Article
GH, IGF-1, and Age Are Important Contributors to Thyroid Abnormalities in Patients with Acromegaly
Table 2
Risk factors of thyroid abnormalities in patients with acromegaly.
| | Patients with normal thyroid () | Patients with thyroid abnormalities () | value | Binary logistic regression analysis | OR (95% CI) | value |
| Sex (n, %) | | | | | | Male | 28 (38.9) | 12 (57.1) | 0.137 | 0.628 (0.198–1.992) | 0.249 | Female | 44 (61.1) | 9 (42.9) | Age (years) | 44.38 ± 12.51 | 31.48 ± 8.87 | <0.001 | 1.092 (1.034–1.154) | 0.002 | Acromegaly duration (months) | 60 (20, 114) | 36 (18, 66) | 0.089 | 1.002 (0.992–1.013) | 0.661 | Pituitary adenoma volume (cm3) | 1.15 (0.34, 2.66) | 2.26 (0.71, 5.68) | 0.223 | 1.027 (0.810–1.301) | 0.828 | Thyroid volume (cm3) | 24.32 ± 14.16 | 20.36 ± 8.56 | 0.284 | 1.028 (0.959–1.102) | 0.432 | BMI (kg/m2) | 27.08 ± 3.94 | 25.56 ± 4.16 | 0.136 | 1.122 (0.944–1.335) | 0.192 | TSH (μIU/ml) | 1.63 ± 1.47 | 1.36 ± 0.93 | 0.433 | N/A | N/A | T3 (ng/ml) | 0.99 ± 0.31 | 1.02 ± 0.29 | 0.781 | N/A | N/A | T4 (μg/dl) | 8.86 ± 2.07 | 8.33 ± 1.76 | 0.303 | N/A | N/A | Random GH (ng/ml) | 15.25 (8.60, 52.50) | 12.0 (7.30, 33.95) | 0.212 | 1.013 (0.996–1.029) | 0.127 | Nadir GH (ng/ml) | 10.45 (5.70, 38.30) | 7.04 (4.94, 22.03) | 0.194 | 1.014 (0.996–1.032) | 0.135 | IGF-1 (ng/ml) | 849.65 ± 310.01 | 822.16 ± 214.02 | 0.719 | 1.001 (0.999–1.003) | 0.393 | GH burden (months ng/ml) | 1321.8 (313.2, 3360.0) | 463.8 (187.2, 1180.0) | 0.036 | 1.000 (1.000–1.001) | 0.090 |
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values less than 0.05; values less than 0.01.
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