Review Article
MicroRNA and Microvascular Complications of Diabetes
Table 3
MicroRNAs involved in diabetic neuropathy.
| miRNA | Source | Model | miRNA levels | Putative targets | Pathogenic role | Reference |
| 146 | Sciatic nerve | db/db mice | ↓ | IRAK1/2 TRAF6 | ↑ inflammation, apoptosis | [31, 32] | | STZ-DM rats | ↑ | IRAK1/2 TRAF6 | Dysfunctional NF-кB-miR-146a negative feedback loop | [27] | let-7i | DRG neurons | STZ-DM mice | ↓ | — | ↓ neurotrophism regeneration | [51] | 29b | DRG neurons | STZ-DM rats | ↓ | Sp1 (?) | ↑ apoptosis, ↓ regeneration | [40] | 29c | DRG neurons, sciatic nerve, and foot pad tissues | db/db mice | ↑ | PRKCI | ↓ axonal growth | [53] | 341 | DRG neurons | STZ-DM mice | ↑ | — | Unknown | [51] |
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DRG: dorsal root ganglia; STZ: streptozotocin; DM: diabetic.
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