The Role of Uron and Chlorobenzene Derivatives, as Potential Endocrine Disrupting Compounds, in the Secretion of ACTH and PRL

Figure 3

EDC effects in the regulation of ACTH release on normal rat AdH cultures, in vitro. Mean (ACTH level) ± SEM. The mean and SEM are calculated from . Abbreviations: B = corticosterone: 1 μg/ml; AVP = 8-arginine vasopressin: 10⁻⁶ M, +B+AVP: in combination therapy B precedes AVP administration by 20 minutes; dClB = 1,4-dichlorobenzene: 0.1 ng/ml; mClB = chlorobenzene mix: 0.1 ng/ml; PU = phenuron: 10⁻⁶ M; MU = monuron: 10⁻⁶ M; DU = diuron: 10⁻⁶ M. All EDC groups differ significantly from the control () for +AVP.