Efficacy and Safety of Insulin Degludec versus Insulin Glargine: A Systematic Review and Meta-Analysis of Fifteen Clinical Trials

Table 3

The design and quality assessment of individual study.

Study, year	Study design	Descriptions of randomization	Double blinding	Dropouts and withdrawals	Jadad score
Zinman et al., 2011 [10]	Multicenter, parallel group trial	2	0	1	3
Birkeland et al., 2011 [11]	Multicenter, parallel group trial	2	0	1	3
Zinman et al., 2012 [12]	Multicenter, parallel group trial	2	0	1	3
Garber et al., 2012 [13]	Multicenter, parallel group trial	2	0	1	3
Heller et al., 2012 [14]	Multicenter, parallel group trial	2	0	1	3
Onishi et al., 2013 [20]	Multicenter, parallel group trial	2	0	1	3
Gough et al., 2013 [21]	Multicenter, parallel group trial	2	0	1	3
Mathieu et al., 2013 [22]	Multicenter, parallel group trial	2	0	1	3
Meneghini et al., 2013 [23]	Multicenter, parallel group trial	2	0	1	3
Pan et al., 2016 [16]	Multicenter, parallel group trial	2	0	1	3
DEVOTE trial, 2017 [24]	Multicenter, parallel group trial	2	2	1	5
Iga et al., 2017 [25]	Single-center, crossover trial	2	0	1	3
Warren et al., 2017 [17]	Multicenter, crossover trial	2	0	1	3
Lane et al., 2017 [26]	Multicenter, crossover trial	2	2	1	5
Wysham et al., 2017 [18]	Multicenter, crossover trial	2	2	1	5

The Jadad scale consists of three items related to descriptions of randomization (0–2 points), double blinding (0–2 points), and dropouts and withdrawals (0-1 point) for a total of five scores. Higher scores indicate better quality. High-quality trials were defined as those that scored more than 2. Low-quality trials were defined as those that scored 2 or less.