Changes in Body Compositions and Basal Metabolic Rates during Treatment of Graves’ Disease
Table 1
Change of biochemical parameter during 1 year of antithyroid treatment.
Baseline
4 wk
8 wk
12 wk
26 wk
52 wk
Free T4 (ng/dL)
3.32 ± 1.46
2.00 ± 0.87
1.28 ± 0.61
1.38 ± 0.72
1.00 ± 0.22
1.10 ± 0.25
Total T4 (μg/dL)
16.0 ± 5.5
7.6 ± 4.2
6.2 ± 1.5
7.8 ± 1.9
Free T3 (ng/dL)
2.21 ± 1.63
0.57 ± 0.47
0.38 ± 0.08
0.40 ± 0.13
Total T3 (ng/dL)
295 ± 140
206 ± 88
131 ± 45
137 ± 74
109 ± 28
107 ± 34
TSH (μIU/mL)
0.01 ± 0.00
0.01 ± 0.00
0.06 ± 0.10
0.99 ± 0.99
3.30 ± 5.74
1.74 ± 1.66
TSH receptor antibody (IU/L)
17.99 ± 13.65
14.13 ± 13.87
12.15 ± 12.79
10.97 ± 12.99
7.65 ± 9.43
4.43 ± 4.92
Peripheral deiodinase activity (, nmol/s)
156 ± 78
84 ± 31
79 ± 12
76 ± 17
Thyroid’s secretory capacity (, pmol/s)
623 ± 215
165 ± 259
95 ± 142
76 ± 179
Total cholesterol (mg/dL)
158 ± 46
210 ± 53
203 ± 46
221 ± 47
Triglyceride (mg/dL)
99 ± 54
85 ± 45
90 ± 34
96 ± 56
HDL cholesterol (mg/dL)
48 ± 9
57 ± 9
54 ± 11
54 ± 11
LDL cholesterol (mg/dL)
90 ± 32
136 ± 41
131 ± 31
148 ± 37
AST (IU/L)
48 ± 31
39 ± 20
21 ± 8
20 ± 7
ALT (IU/L)
78 ± 71
60 ± 51
19 ± 15
21 ± 24
ALP (IU/L)
101 ± 60
118 ± 60
106 ± 51
62 ± 10
compared to baseline values; peripheral deiodinase activity () and thyroid’ secretory capacity () were calculated with the equations described in Materials and Methods.
