Identifying and Validating Genes with DNA Methylation Data in the Context of Biological Network for Chinese Patients with Graves’ Orbitopathy

Table 2

Topological properties of LMG- and HMG-regulated networks.

Topological properties	LMG-regulated network	HMG-regulated network
Number of nodes	42	42
Network density	0.367	0.374
Network heterogeneity	0.229	0.165
Clustering coefficient	0.463	0.458
Network diameter	3	3
Network centralization	0.127	0.094
Shortest paths	1722	1722
Characteristic path length	1.646	1.627

HMGs: high methylated genes; LMGs: low methylated genes; number of nodes: the number of nodes in the network; network density: the portion of the potential connections in a network that are actual connections; network heterogeneity: the tendency of a network to contain hub nodes; clustering coefficient: the probability that two vertices connected to the same node are also connected; network diameter: the largest distance between two nodes; network centralization: networks whose topologies resemble a star have centralization close to 1, whereas decentralized networks are characterized by having centralization close to 0; shortest paths: the length of the shortest path between two nodes; characteristic path length: the average shortest path length, which is the expected distance between two connected nodes.