Increased Circulating Chemerin in Relation to Chronic Microvascular Complications in Patients with Type 2 Diabetes
Table 1
Baseline characteristics of patients with and without microvascular complications.
All
Without complication
With complication
p
Number (n)
598
131
467
NS
Age (years)
54.56(12.14)
53.91 (12.21)
54.74(12.12)
NS
Sex (male/female)
383/215
90/41
293/174
NS
Duration of diabetes (years)△
8(3,13)
2(0.8,9)
10(5,15)
<0.001
Waist circumference (cm)
87.30(9.40)
86.63 (11.12)
87.37(9.23)
NS
BMI (kg/m2)
25.38(3.52)
24.91(3.46)
25.51(3.52)
NS
SBP (mmHg)
127.05(14.57)
125.01(13.26)
127.63(14.88)
NS
DBP (mmHg)
79.28(6.62)
78.37(7.47)
79.53(6.35)
NS
Glycated hemoglobin (%)
8.71(1.87)
8.03(1.45)
8.91(1.92)
<0.001
Triglycerides (mmol/l) △
1.65(1.17,2.57)
1.62(1.15,2.21)
1.70(1.19,2.76)
NS
Total cholesterol (mmol/l)
4.76(1.05)
4.62(1.03)
4.79(1.05)
NS
HDL cholesterol (mmol/l)
1.09(0.33)
1.07(0.30)
1.10(0.34)
NS
LDL cholesterol (mmol/l)
2.81(0.84)
2.77(0.75)
2.82(0.87)
NS
Scr (umol/l)
61.70(23.12)
55.53(13.58)
63.44(24.89)
0.001
UAE (mg/24h)△
22.4(12.4,107.1)
13.2(9,17.0)
36.8(14.4,188.76)
<0.001
hs-CRP (mg/L) △
4.70(1.8,8.60)
3.6(1.2,6.6)
5.0 (2.0,8.8)
0.021
Chemerin (ng/ml)
114.78(43.62)
97.69(40.27)
119.54(43.37)
<0.001
Medication
Oral hypoglycemic agents
139 (23.2%)
33(25.1%)
106(22.69%)
NS
Insulin
459 (76.8%)
98(74.9%)
361(78.31%)
NS
Hypertension (%)
364(60.8%)
71(54.19%)
293(62.7%)
NS
Microvascular complications
Nephropathy (%)
261(43.6)
Retinopathy (%)
209(34.9)
Neuropathy (%)
201(33.6)
One complication (%)
322(53.8)
Two complications (%)
86(14.4)
Three complications (%)
59(9.9)
Numerical variables are expressed as the mean with SD and median (interquartile range). Categorical variables were presented as number (percentage). P-value for difference between the groups was calculated from the analysis of Student’s t test. BMI, body mass index; SBP, systolic blood pressure; DBP, diastolic blood pressure; Scr, serum creatinine; UAE, urinary albumin excretion; hs-CRP, high sensitivity C-reactive protein; NS, not significant. △Natural logarithmic transformation was used in analysis.
