Increased Circulating Chemerin in Relation to Chronic Microvascular Complications in Patients with Type 2 Diabetes
Table 4
Clinical characteristics in type 2 diabetic patients with normoalbuminuria, microalbuminuria, and macroalbuminuria.
Normoalbuminuria
Microalbuminuria
Macroalbuminuria
p
Number (n)
131
90
38
Age (years)
53.91 (12.21)
52.75(12.72)
55.55(13.98)
NS
Sex (male/female)
90/41
57/33
30/8
NS
Duration of diabetes (years)△
2(0.8,9)
6(5,11)∗
6.5(3,13.5)∗
<0.001
Waist circumference (cm)
86.63 (11.12)
88.53(8.53)
86.7(8.12)
NS
BMI (kg/m2)
24.91(3.46)
25.71(3.6)
25.73(2.7)
NS
SBP (mmHg)
125.01(13.26)
126.74(12.96)
125.84(10.58)
NS
DBP (mmHg)
78.37(7.47)
79.10(6.24)
80.02(5.21)
NS
Glycated hemoglobin (%)
8.03(1.45)
8.69(1.85)∗
9.42(1.73)∗
<0.001
Triglycerides (mmol/l) △
1.62(1.15,2.21)
3.0(1.68,4.51)∗
2.00(1.05,5.32)∗
<0.001
Total cholesterol (mmol/l)
4.62(1.03)
4.88(0.98)
4.88(0.86)
NS
HDL cholesterol (mmol/l)△
1.07(0.30)
1.02(0.28)
1.05(0.24)
NS
LDL cholesterol (mmol/l)
2.77(0.75)
2.88(0.83)
3.03(0.68)
NS
Scr (umol/l)
55.53(13.58)
68.15(25.12)∗
80.84(32.89)∗#
<0.001
hs-CRP (mg/L) △
3.6(1.2,6.6)
5.4(2.1,9.05)∗
6.3(3.6,12.5)∗
0.001
Chemerin (ng/ml)
97.69(40.27)
112.93(43.40)∗
135.08(65.42)∗#
<0.001
Medication
Oral hypoglycemic agents
33(25.1%)
31(34.4%)
9(23.7%)
NS
Insulin
98(74.9%)
59(65.6%)
29(76.3%)
NS
Hypertension (%)
71(54.19%)
57(63.3%)
26(68.42%)
NS
Numerical variables are expressed as the mean with SD and median (interquartile range). Categorical variables were presented as number (percentage). P-value for difference between the groups was calculated from the analysis of one-way ANOVA, ∗vs. Normoalbuminuria group, and # vs. Microalbuminuria group. BMI, body mass index; SBP, systolic blood pressure; DBP, diastolic blood pressure; Scr, serum creatinine; hs-CRP, high sensitivity C-reactive protein; NS, not significant. △Natural logarithmic transformation was used in analysis.
