Parathyroid Hormone is Negatively Correlated with Glycated Hemoglobin in Newly Diagnosed Type 2 Diabetic Patients

Table 2

Baseline characteristics of the newly diagnosed T2D patients with various levels of HbA1c.

	Tertile of HbA1c(n = 387)
	Lower HbA1c group (n = 129)	Medium HbA1c group (n = 129)	Higher HbA1c group (n = 129)
Age (years)	46.7 ± 11.1	45.8 ± 11.7	43.9 ± 11.7	0.144
Sex, male, (n) %	98 (75.9%)	93 (72.0%)	90 (69.7%)	0.529
Symptomatic (n) %	56 (43.4%)	70 (54.3%)^a	90 (69.8%)^ab	<0.001
Season, summer, (n) %	34 (26.3%)	33 (25.5%)	35 (27.1%)	0.961
BMI (kg/m^2)	27.12 ± 3.20	26.84 ± 3.33	26.60 ± 3.45	0.451
TC (mmol/L)	4.82 ± 0.74	4.84 ± 0.94	5.11 ± 1.04^a	0.024
LDL-C (mmol/L)	3.05 ± 0.77	3.05 ± 0.88	3.23 ± 1.11	0.211
HDL-C (mmol/L)	0.99 (0.80, 1.10)	0.94 (0.80, 1.10)	0.90 (0.79, 1.00)	0.041
TG (mmol/L)	1.76 (1.34, 2.52)	1.78 (1.18, 2.63)	1.75 (1.31, 2.68)	0.733
FFA (mmol/L)	0.52 (0.42, 0.66)	0.50 (0.38, 0.61)	0.49 (0.38, 0.63)	0.063
Crea (μmol/L)	64.10 (52.90, 74.10)	57.60 (47.20, 66.10)^a	57.80 (49.40, 66.80)^a	<0.001
FBG (mmol/L)	7.18 (6.05, 8.29)	8.00 (6.59, 9.57)^a	9.35 (7.41, 11.45)^ab	<0.001
FINS (μIU/mL)	9.30 (6.95, 12.92)	10.30 (7.00, 13.90)	10.10 (7.20, 12.90)	0.705
HbA1c (%)	9.00 (8.15, 9.70)	10.60 (10.40, 10.80)^a	12.30 (11.55, 12.95)^ab	<0.001
HOMA-IR	3.03 (2.03, 4.39)	3.50 (2.46, 5.20)	3.98 (2.86, 5.41)^a	0.001
HOMA-β	54.21 (34.92, 76.29)	40.31 (27.54, 68.83)	35.08 (21.85, 56.90)^a	<0.001
Ca (mmol/L)	2.30 ± 0.09	2.31 ± 0.09	2.30 ± 0.11	0.728
P (mmol/L)	1.29 ± 0.20	1.34 ± 0.20	1.31 ± 0.20	0.126
25-OH-D3 (ng/mL)	15.63 (11.05, 18.77)	14.20 (10.90, 19.60)	13.93 (10.73, 20.89)	0.773
PTH (pg/mL)	37.50 (26.10, 54.55)	36.00 (26.65, 46.50)	32.90 (24.85, 41.40)^a	0.031

Data are shown as the means ± S.D. unless indicated otherwise. HDL-C, TG, FFA, FBG, FINS, HbA1c, HOMA-IR, HOMA-β, 25-OH-D3, and PTH are shown as the median ( and ). Male and season are shown as n (%). HbA1c, glycated hemoglobin; symptomatic: polydipsia, polyuria and loss of weight; BMI, body mass index; TC, total cholesterol; LDL-C, low-density lipoprotein cholesterol; HDL-C, high-density lipoprotein cholesterol; TG, triglycerides; FFA, free fatty acids; Crea, creatinine; FBG, fasting blood glucose; FINS, fasting plasma insulin; HOMA-IR, homeostasis model assessment of insulin resistance; HOMA-β, homeostasis model assessment of β-cell function; Ca, blood calcium; P, blood phosphorus; 25-OH-D3, 25-hydroxyvitamin D3; PTH, parathyroid hormone. Compared with the lower HbA1c group, ^asignificantly different at . Compared with the medium HbA1c group, ^bsignificantly different at .