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Obesity-Related Metabolic Syndrome and Vascular Complications

Call for Papers

Obesity is a major public health problem and its levels are rising at an alarming rate and so is the incidence of obesity-related disorders, such as the metabolic syndrome, type 2 diabetes, and cardiovascular diseases. The vascular damage in obesity derives from a variety of changes in the adipose tissue, leading to a chronic inflammatory state and to dysregulation of adipocyte-derived factors. A variety of pathophysiological mechanisms have been involved to link central adiposity and metabolic syndrome. In particular, insulin resistance and hyperinsulinemia are considered the key factors in determining the constellation of abnormalities characteristic of the metabolic syndrome. Elucidation of the mechanisms underlying vascular damage in obese patients is necessary to identify new pharmacologic targets to prevent the cardiovascular complications of metabolic syndrome and their human and economic costs.

We invite investigators to submit original research articles, as well as review articles, that will contribute to a better understanding of the putative mechanisms, whereby obesity-related metabolic syndrome affects vascular function. Potential topics include, but are not limited to:

  • Obesity-related changes in adipose tissue
  • Inflammatory cytokines in vascular dysfunction and vascular disease
  • Role of obesity/insulin resistance on endothelial dysfunction and atherosclerosis
  • Vasoactive properties of insulin and metabolic syndrome
  • Obesity and endothelial dysfunction
  • Oxidative stress
  • Obesity, metabolic syndrome, and renal function
  • Dysregulation of adipokines during obesity and type 2 diabetes
  • The role of adipokines in insulin resistance and vascular function
  • Role of perivascular adipose tissue (PVAT) on vascular function
  • Effects of obesity and adipokines on sympathetic activity

Before submission authors should carefully read over the journal’s Author Guidelines, which are located at http://www.hindawi.com/journals/ije/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/submit/journals/ije/ovas/ according to the following timetable:

Manuscript DueFriday, 28 June 2013
First Round of ReviewsFriday, 20 September 2013
Publication DateFriday, 15 November 2013

Lead Guest Editor

  • Manfredi Tesauro, Department of Internal Medicine, University of Tor Vergata, 00133 Rome, Italy

Guest Editors

  • Micaela Iantorno, Critical Care Medicine Department, National Institutes of Health, 10 Center Drive, Room 2C145, Bethesda, MD, USA
  • Umberto Campia, Department of Cardiology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA