Primary Prevention of Diabetic Complications: Early Risk Detection and Intervention

Call for Papers

Diabetic complications are a global leading cause of morbidity and mortality and constitute a major economic burden worldwide. On an individual level, diabetic complications deteriorate the quality of life. Recent large randomized clinical trials seem to indicate that once diabetic complications have developed, it is difficult to reverse organ injury, even when intensive glycemic-recuduction therapies are implemented. At the same time, though, long-term posttrial follow-up results have revived the concept of metabolic memory (or legacy effect).

More profound knowledge and understanding of the mechanisms leading to the development of diabetes complications, even in the absence of overt impaired glucose tolerance (IGT)/impaired fasting glucose (IFG), is warranted. The identification of early markers for the risk of developing “diabetic”� complications, even before the onset of IGT/IGF (WHO/ADA) could contribute to minimize long-term diabetic complications.

We invite investigators to submit original research articles, as well as review articles, that will contribute to the understanding of the early processes related to the development of diabetes complications. We are interested in articles dealing with early risk identification, prevention, and mitigation of the development of diabetes complications.

Potential topics, related to the prevention of diabetes complications [heart diseases (e.g., coronary artery disease and heart failure; arrhythmias)]; cerebrovascular disease; peripheral artery disease; kidney disease; eye disease; peripheral neuropathy; autonomic neuropathies (e.g., gastroparesis, cardiac autonomic neuropathy, and genitourinary pathology) include, but are not limited to:

• Identifying biomarkers that predict risk of developing diabetes complications
• Development of clinical tests that can predict the risk of diabetic complications
• Genetic susceptibility to diabetes-related complications
• Development and testing of novel treatment targets in the prevention of diabetic complications
• Abnormal metabolic regulation and cardiovascular risk
• Early detection of diabetes cardiovascular complications and interventions to prevent further damage
• Elucidating the risk/benefit profile of early treatment intervention in the prevention of diabetic complications
• Cost-effectiveness of interventions to prevent and control diabetes complications
• Effect of the current diabetes diagnostic criteria on patient/physician unawareness and inertness, in relation to early detection and treatment of diabetes complications

Before submission authors should carefully read over the journal's Author Guidelines, which are located at http://www.hindawi.com/journals/ije/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/submit/journals/ije/dcomp/ according to the following timetable:

Lead Guest Editor

• Atheline Major-Pedersen, Safety Surveillance Diabetes Global Safety, Novo Nordisk A/S, 2880 Bagsværd, Denmark

Guest Editors

• Gunnar Gislason, Department of Cardiology, Copenhagen University Hospital Gentofte, 2900 Hellerup, Denmark
• Roberto Miccoli, Department of Endocrinology and Metabolism, University of Pisa, Pisa, Italy
• Peter Rossing, Steno Diabetes Research Center, 2820 Gentofte, Denmark