Graves’ Orbitopathy
1Kurume University, Kurume, Japan
2The University of Sydney, Sydney, Australia
3Gutenberg University, Mainz, Germany
4Aichi Medical University, Nagakute, Japan
Graves’ Orbitopathy
Description
Graves’ orbitopathy (GO) is an autoimmune disorder of the orbit that is closely associated with autoimmune thyroid diseases (AITD). Although the primary autoantigen(s) and precise mechanisms underlying the association between GO and AITD remain unclear, TSH receptors are thought to be the primary target of autoimmune reactions in GO patients.
We invite investigators to contribute original research articles as well as review articles that will stimulate the continuing efforts to understand the molecular pathology and mechanisms for the development of GO. Significant progress has been made in research on genetics, epigenetics, and animal models of GO. We also invite articles describing the new insights on clinical features, diagnosis, and managements of GO, including molecular target therapy using small molecules.
Potential topics include, but are not limited to:
- Pathogenesis of GO: role of TSH receptor and IGF-1R antibodies; role of fibrocytes; animal models
- Advances in genetics and epigenetics of GO
- Clinical assessment and diagnosis of GO: identifying biomarkers; orbital imaging
- Management of GO: medical therapy; radiotherapy; orbital decompression and rehabilitative surgery; small molecule targeted therapy
- Translational topic between autoimmune thyroid diseases and GO